{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:24:09Z","timestamp":1784780649782,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,5]],"date-time":"2017-03-05T00:00:00Z","timestamp":1488672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Correction of coagulopathy prior to central venous catheter (<jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content>) placement is advocated by guidelines, while retrospective studies support restrictive use of transfusion products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We conducted a mixed vignette and questionnaire web survey to investigate current practice and preferences for <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> placement. Clinical vignettes were used to quantify the tendency to administer platelet concentrate. A positive \u00df\u2010coefficient is in favour of administering platelet concentrate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010seven physicians answered the survey questions (36 critical care physicians, 14 haematologists, 20 radiologists and 27 anaesthesiologist). Eighty\u2010six physicians subsequently completed the clinical vignettes (response rate 71%). Preferences in favour of correcting thrombocytopenia prior <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> placement were platelet counts of 10 \u00d7 10<jats:sup>9<\/jats:sup>\/L and 20 \u00d7 10<jats:sup>9<\/jats:sup>\/L (\u00df = 3\u00b79; \u00df = 3\u00b72, respectively), the subclavian insertion site (\u00df = 0\u00b78). An elevated <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> = 3; \u00df = 0\u00b76) and an elevated <jats:styled-content style=\"fixed-case\">aPTT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">aPTT<\/jats:styled-content> = 60 s; \u00df = 0\u00b74) showed a positive trend towards platelet transfusion. Platelet transfusion was less likely in an emergency setting (\u00df = \u22120\u00b74). Reported transfusion thresholds for <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> placement varied from &lt;10 \u00d7 10<jats:sup>9<\/jats:sup>\/L to 80 \u00d7 10<jats:sup>9<\/jats:sup>\/L for platelet count, from 1\u00b70 to 10\u00b70 for <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> and from 25 s to 150 s for <jats:styled-content style=\"fixed-case\">aPTT<\/jats:styled-content>. Implementation of ultrasound guidance as standard practice was limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current transfusion practice prior to <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> placement is highly variable. Physicians adjust the decision to correct coagulopathy prior <jats:styled-content style=\"fixed-case\">CVC<\/jats:styled-content> placement based on clinical parameters, insertion site and technique applied.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12498","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T03:32:42Z","timestamp":1488771162000},"page":"343-351","source":"Crossref","is-referenced-by-count":15,"title":["The practice of platelet transfusion prior to central venous catheterization in presence of coagulopathy: a national survey among clinicians"],"prefix":"10.1111","volume":"112","author":[{"given":"E. K.","family":"van de Weerdt","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Centre Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A.) Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. L.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Centre Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A.) Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J.","family":"Goudswaard","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Binnekade","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. P.","family":"van Lienden","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. J.","family":"Biemond","sequence":"additional","affiliation":[{"name":"Department of Haematology Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. P. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Academic Medical Centre Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A.) 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