{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:47:37Z","timestamp":1792453657326,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Australian Governments"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Serum eye drops (<jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s) are used to treat dry eye syndrome and non\u2010healing corneal lesions when other treatments fail. Despite many clinical studies demonstrating the efficacy of both autologous and allogeneic <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s, there is no internationally harmonized method for producing <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A 40\u2010question survey requesting information regarding donor selection, blood collection and processing, infectious disease screening, shelf life and regulatory requirements for the production of autologous and allogeneic <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s was developed by the Biomedical Excellence for Safer Transfusion Collaborative. Survey data were collected into a database via a secure web interface and then downloaded into Excel for further analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 55 responses were received, with 21 responses from centres indicating they produce <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s. Based on the responses, collection and processing practices differ widely, according to the size of the centre making the <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s, and their ability to collect, process and test the blood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite divergences in the methods for producing <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s, the end result is a small\u2010volume aliquot of serum that can be administered by a patient at home. If more centres move from producing autologous to allogeneic <jats:styled-content style=\"fixed-case\">SED<\/jats:styled-content>s, this may provide an opportunity for production methods to become more standardized internationally.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12502","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T04:57:07Z","timestamp":1490331427000},"page":"310-317","source":"Crossref","is-referenced-by-count":35,"title":["Serum eye drops: a survey of international production methods"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"D. C.","family":"Marks","sequence":"first","affiliation":[{"name":"Research and Development Australian Red Cross Blood Service Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2093-3604","authenticated-orcid":false,"given":"P. 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