{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T01:14:55Z","timestamp":1767921295322,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001729","name":"Stiftelsen f\u00f6r\u00a0Strategisk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Allogeneic hematopoietic stem cell transplantation (<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> are associated with high mortality and morbidity. Typical infectious agents are Epstein\u2013Barr virus, cytomegalovirus, herpes simplex virus, varicella\u2010zoster virus and fungi. The study aim was to evaluate whether measurement of the responses of antigen\u2010specific T\u2010cells, recognizing infectious pathogens would correlate to protective functions in the stem cell recipient post\u2010transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010one grafts were analysed by flow cytometry and cells were stimulated <jats:italic>in vitro<\/jats:italic> with relevant infectious antigens, followed by evaluation of T\u2010cell proliferation and cytokine production. Results were compared to the recipients\u2019 clinical records 1\u2010year post\u2010transplantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We show that an extensive repertoire of transferred antigen\u2010specific T\u2010cells from allogeneic donor grafts against infectious agents, involved in post\u2010transplant infections, are linked to an absence of infectious complications for the recipient up\u2010to 1\u2010year post\u2010transplant. The protective effect was associated with antigen\u2010specific T\u2010cell proliferation and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 secretion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that assaying T\u2010cell function before <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> could determine individual risks for infectious complications and thus aid in clinical decision\u2010making regarding prophylactic and pre\u2010emptive anti\u2010infective therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12521","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T02:56:44Z","timestamp":1493780204000},"page":"459-468","source":"Crossref","is-referenced-by-count":8,"title":["Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"112","author":[{"given":"J.","family":"Nilsson","sequence":"first","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Granrot","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mattsson","sequence":"additional","affiliation":[{"name":"Centre for Allogeneic Stem Cell Transplantation Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Oncology and Pathology Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Omazic","sequence":"additional","affiliation":[{"name":"Clinical Immunology and Transfusion Medicine Karolinska University Hospital Stockholm 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