{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:19:36Z","timestamp":1762507176942,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Platelet concentrates (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>) are transfused to improve primary haemostasis before urgent neurosurgery in patients with intracranial haemorrhage (<jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>) receiving antiplatelet therapy (<jats:styled-content style=\"fixed-case\">APT<\/jats:styled-content>). It is unresolved, whether <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>s increase the risk for major cardio\u2010 and cerebrovascular adverse events. We evaluated a standardized transfusion regimen to reverse <jats:styled-content style=\"fixed-case\">APT<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> who required decompressive neurosurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analysed were consecutive patients between 2012 and 2014. The primary outcome was the frequency of new arterial thrombotic complications. The secondary outcome was the frequency of recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 72 patients, 14 received acetylsalicylic acid and a P2Y<jats:sub>12<\/jats:sub> inhibitor, 53 received acetylsalicylic acid and five clopidogrel. No acute coronary syndrome (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u20135\u00b707) and one ischaemic stroke occurred (1\u00b74%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b725\u20137\u00b746). In contrast, 26\u00b74% of patients developed recurrent <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 17\u00b759\u201337\u00b758). The risk of bleeding was significantly higher compared to the risk of arterial thrombosis (<jats:italic>P<\/jats:italic> &lt; 0\u00b700001) and was increased for patients with chronic <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 4\u00b778; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b757\u201314\u00b755) and those receiving clopidogrel (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 2\u00b778; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b790\u20138\u00b757).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet concentrate transfusion before cranial decompressive surgery in patients with <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> complicating <jats:styled-content style=\"fixed-case\">APT<\/jats:styled-content> showed a low risk for cardio\u2010cerebral thrombotic complications. However, the risk of rebleeding remains high, especially in patients with chronic <jats:styled-content style=\"fixed-case\">ICH<\/jats:styled-content> and those pretreated with clopidogrel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12542","type":"journal-article","created":{"date-parts":[[2017,8,15]],"date-time":"2017-08-15T03:26:41Z","timestamp":1502767601000},"page":"535-541","source":"Crossref","is-referenced-by-count":14,"title":["Platelet transfusion to reverse antiplatelet therapy before decompressive surgery in patients with intracranial haemorrhage"],"prefix":"10.1111","volume":"112","author":[{"given":"M.","family":"Baschin","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Immunologie und Transfusionsmedizin Abteilung Transfusionsmedizin Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Selleng","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr An\u00e4sthesiologie Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010P.","family":"Zeden","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurochirurgie Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Westphal","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Immunologie und Transfusionsmedizin Abteilung Transfusionsmedizin Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kohlmann","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Community Medicine Universit\u00e4tsmedizin Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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