{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T20:32:12Z","timestamp":1769545932078,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009741","name":"National Blood Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Australia introduced bacterial contamination screening (<jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content>) for platelet components in April 2008. This study presents analysis performed to assess the efficacy of testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Seven\u2010day aerobic and anaerobic culture is performed using the BacT\/<jats:styled-content style=\"fixed-case\">ALERT<\/jats:styled-content> 3D system. Following an initial machine positive (<jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>) flag, all associated components are recalled, and\/or clinicians treating already transfused patients are notified. <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>s are categorized as \u2018machine false positive\u2019, \u2018confirmed positive\u2019 or \u2018indeterminate\u2019 depending on culture results of initial and repeat samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2010 and 2012, 1\u00b71% of platelet donations tested <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>; since 2013, this rate has fallen to 0\u00b76% through improved instrument management, reducing false\u2010positive <jats:styled-content style=\"fixed-case\">IMP<\/jats:styled-content>s but maintaining sensitivity for cultures yielding bacterial growth. On average, 66% of confirmed positive and indeterminate platelet units had been transfused at the time of detection. The majority (95%) of these grew <jats:italic>Propionibacterium<\/jats:italic> sp., a slow\u2010growing organism that rarely causes sepsis in the transfusion setting. The incidence of reported transfuion\u2010transmitted bacterial infection (<jats:styled-content style=\"fixed-case\">TTBI<\/jats:styled-content>) has fallen since the introduction of <jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content>, with a 4\u00b72\u2010fold [0\u00b75, 28\u00b72] lower rate from platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content> has been successful in detecting platelet units containing pathogenic bacteria. The incidence of <jats:styled-content style=\"fixed-case\">TTBI<\/jats:styled-content> from platelets has fallen since the introduction of <jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content>, but the risk has not been eliminated due to rare false\u2010negative results. In the absence of a pathogen inactivation system for red blood cells, <jats:styled-content style=\"fixed-case\">BCS<\/jats:styled-content> provides \u2018surrogate\u2019 testing of red blood cells from which platelets have been manufactured.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12561","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T04:43:01Z","timestamp":1506487381000},"page":"13-20","source":"Crossref","is-referenced-by-count":31,"title":["Bacterial testing of platelets \u2013 has it prevented transfusion\u2010transmitted bacterial infections in Australia?"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-1763","authenticated-orcid":false,"given":"J.","family":"Thyer","sequence":"first","affiliation":[{"name":"Australian Red Cross Blood Service Melbourne Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Perkowska\u2010Guse","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service Melbourne Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Ismay","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service Melbourne Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Keller","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service Melbourne Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. T.","family":"Chan","sequence":"additional","affiliation":[{"name":"Australian Red Cross Blood Service Melbourne Vic Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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