{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:06:11Z","timestamp":1761156371410,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Foundation for Scientific Research of the Belgian Red Cross"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Pathogen inactivation methods for platelet concentrates are increasingly being used in blood banks worldwide. <jats:italic>In vitro<\/jats:italic> studies have demonstrated its effects on storage lesion, but little routine quality control data on blood banking outcomes have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Swirling of distributed products was monitored before and after implementation of Intercept pathogen inactivation. Metabolic parameters <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, glucose and lactic acid were determined in a random cohort of expired pathogen\u2010inactivated products. Storage lesion indicators in apheresis concentrates with premature low swirling were compared to concentrates with normal swirling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During validation for implementing Intercept pathogen inactivation, <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content> and glucose levels decreased faster in apheresis platelet concentrates with high platelet content than with low platelet content or than in pathogen\u2010inactivated pooled buffy coat\u2010derived products. In routine products, glucose exhaustion was more often found in apheresis compared to buffy coat\u2010derived platelet concentrates despite 3\u20137% more plasma carryover in the former. Annual incidence of premature low swirling increased significantly by 50% following implementation of pathogen inactivation implementation for apheresis but not for pooled buffy coat platelet concentrates. In addition, apheresis concentrates with premature low swirling had a significantly higher median platelet count (5\u00b70 \u00d7 10<jats:sup>11<\/jats:sup>) than unaffected products (3\u00b75 \u00d7 10<jats:sup>11<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The risk of increased storage lesion rates following Intercept pathogen inactivation is higher for apheresis than for buffy coat\u2010derived platelet concentrates, especially when platelet contents are higher than 5\u00b70 \u00d7 10<jats:sup>11<\/jats:sup>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12596","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T07:28:30Z","timestamp":1506497310000},"page":"751-758","source":"Crossref","is-referenced-by-count":13,"title":["High platelet content can increase storage lesion rates following Intercept pathogen inactivation primarily in platelet concentrates prepared by apheresis"],"prefix":"10.1111","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-8852","authenticated-orcid":false,"given":"H. B.","family":"Feys","sequence":"first","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross\u2010Flanders Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Devloo","sequence":"additional","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross\u2010Flanders Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Sabot","sequence":"additional","affiliation":[{"name":"Blood Service of the Belgian Red Cross\u2010Flanders Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"De Pourcq","sequence":"additional","affiliation":[{"name":"Blood Service of the Belgian Red Cross\u2010Flanders Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Coene","sequence":"additional","affiliation":[{"name":"Blood Service of the Belgian Red Cross\u2010Flanders Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Compernolle","sequence":"additional","affiliation":[{"name":"Transfusion Research Center Belgian Red Cross\u2010Flanders Ghent Belgium"},{"name":"Faculty of Medicine and Health Sciences Ghent University Ghent Belgium"},{"name":"Blood Service of the Belgian Red Cross\u2010Flanders Ghent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12053"},{"key":"e_1_2_8_3_1","first-page":"255","article-title":"In vitro evaluation of pathogen\u2010inactivated buffy coat\u2010derived platelet concentrates during storage: psoralen\u2010based photochemical treatment step\u2010by\u2010step","volume":"13","author":"Abonnenc M","year":"2015","journal-title":"Blood 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