{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:51:51Z","timestamp":1790614311029,"version":"4.1.0"},"reference-count":93,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T00:00:00Z","timestamp":1512000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>Transfusion\u2010transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion\u2010transmitted infections (<jats:styled-content style=\"fixed-case\">TTI<\/jats:styled-content>s), dependence on high\u2010risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>), hepatitis B and C (<jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) and syphilis. Barriers to implementation of broader molecular methods include cost, limited infrastructure and lack of technical expertise. Pathogen reduction (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>), a term used to describe a variety of methods (e.g. solvent detergent treatment or photochemical activation) that may be applied to blood following collection, offers the means to diminish the infectious potential of multiple pathogens simultaneously. This is effective against different classes of pathogen, including the major <jats:styled-content style=\"fixed-case\">TTI<\/jats:styled-content>s where laboratory screening is already implemented (e.g. <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HBV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) as well pathogens that are widely endemic yet remain unaddressed (e.g. malaria, bacterial contamination). We sought to review the available and emerging <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> techniques and their potential application to resource\u2010constrained parts of Africa, focusing on the advantages and disadvantages of such technologies. <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> has been slow to be adopted even in high\u2010income countries, primarily given the high costs of use. Logistical considerations, particularly in low\u2010resourced parts of Africa, also raise concerns about practicality. Nonetheless, <jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content> offers a rational, innovative strategy to contend with <jats:styled-content style=\"fixed-case\">TTI<\/jats:styled-content>s; technologies in development may well present a viable complement or even alternative to targeted screening in the future.<\/jats:p>","DOI":"10.1111\/vox.12620","type":"journal-article","created":{"date-parts":[[2017,11,30]],"date-time":"2017-11-30T07:18:41Z","timestamp":1512026321000},"page":"3-12","source":"Crossref","is-referenced-by-count":49,"title":["Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low\u2010resource settings"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-3375","authenticated-orcid":false,"given":"A. 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