{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:03:01Z","timestamp":1785250981158,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The rate of confirmed hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) cases, in first\u2010time donors, is much lower in 2015 than 20 years ago. We investigate reasons for the decline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> rates were analysed by gender and birth cohort for 1996 to 2015 and ethnic group for 2006 to 2015. Variables for confirmed positive cases were compared for two ten\u2010year periods (1996 to 2005 and 2006 to 2015) including genotyping data for 2006 to 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 2007 confirmed <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cases identified between 1996 and 2015. The rate per 100 000 donations fell from 78\u00b76 in 1996 to 26\u00b79 by 2015. By birth cohort, <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> rates were highest in donors born in the 1950s and 1960s who contributed a decreasing proportion of first\u2010time donors. Between 2006 and 2015, there was no significant decline in <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> rate. The <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive donor profile has changed in the last 10 years with increased proportions of younger donors, donors born abroad and decreased reported injecting drug use. Genotype 1a remains predominate, but genotype 1b has increased associated with this change in birth cohort and ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decline in number and rate of confirmed <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive first\u2010time donors is mainly due to a decrease in first\u2010time donors born before 1970, with the highest rate of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. However, the decline has slowed and the profile of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010positive first\u2010time donors is changing. A better understanding of behaviour and sources of <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> in younger and ethnic minority donors are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12638","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T08:22:47Z","timestamp":1518596567000},"page":"329-338","source":"Crossref","is-referenced-by-count":6,"title":["Dissecting the decline of hepatitis C in first\u2010time donors in England and Wales"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-0832","authenticated-orcid":false,"given":"C. A.","family":"Reynolds","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant\/Public Health England Epidemiology Unit NHS Blood and Transplant London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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