{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:26:21Z","timestamp":1774020381800,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"H\u00e9ma-Qu\u00e9bec"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Since 25 May 2010, all donors at our blood centre who tested false\u2010positive for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HBV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HCV<\/jats:styled-content> or syphilis are eligible for re\u2010entry after further testing. Donors who have a second false\u2010positive screening test, either during qualification for or after re\u2010entry, are deferred for life. This study reports on factors associated with the occurrence of such deferrals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Rates of second false\u2010positive results were compared by year of deferral, transmissible disease marker, gender, age, donor status (new or repeat) and testing platform (same or different) both at qualification for re\u2010entry and afterwards. Chi\u2010square tests were used to compare proportions. Cox regression was used for multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participation rates in the re\u2010entry programme were 42\u00b71%: 25\u00b76% failed to qualify for re\u2010entry [different platform: 2\u00b77%; same platform: 42\u00b79% (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001)]. After re\u2010entry, rates of deferral for second false\u2010positive results were 8\u00b74% after 3 years [different platform: 1\u00b78%; same platform: 21\u00b74% (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001)]. Deferral rates were higher for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> than for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> at qualification when tested on the same platform. The risk, when analysed by multivariate analyses, of a second deferral for a false\u2010positive result, both at qualification and 3 years after re\u2010entry, was lower for donors deferred on a different platform; this risk was higher for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HCV<\/jats:styled-content> and syphilis than for <jats:styled-content style=\"fixed-case\">HBV<\/jats:styled-content> and for new donors if tested on the same platform.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Re\u2010entry is more often successful when donors are tested on a testing platform different from the one on which they obtained their first false\u2010positive result.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12644","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T06:12:38Z","timestamp":1520316758000},"page":"339-344","source":"Crossref","is-referenced-by-count":11,"title":["Factors associated with a second deferral among donors eligible for re\u2010entry after a false\u2010positive screening test for syphilis, <scp>HCV<\/scp>,<scp> HBV<\/scp> and <scp>HIV<\/scp>"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-698X","authenticated-orcid":false,"given":"Y.","family":"Gr\u00e9goire","sequence":"first","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec Quebec City QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Germain","sequence":"additional","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec Quebec City QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Delage","sequence":"additional","affiliation":[{"name":"H\u00e9ma\u2010Qu\u00e9bec Montr\u00e9al QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1996.36196190513.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198910053211401"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01844.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01973.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03031.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.10.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00694_57.x"},{"key":"e_1_2_8_9_1","first-page":"10S","article-title":"Re\u2010entry of blood donors with a false positive anti\u2010HCV ELISA result","volume":"40","author":"Ariaansz\u2010Van zanten M","year":"2000","journal-title":"Transfusion"},{"key":"e_1_2_8_10_1","first-page":"11S","article-title":"Re\u2010entry of blood donors with a false positive anti\u2010HTLV ELISA result","volume":"40","author":"Ariaansz\u2010Van zanten M","year":"2000","journal-title":"Transfusion"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00386.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2004.09.004"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1993.33393174457.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:26:40Z","timestamp":1695515200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,6]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/vox.12644"],"URL":"https:\/\/doi.org\/10.1111\/vox.12644","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,6]]}}}