{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:58:09Z","timestamp":1770973089943,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Approaches to preventing transfusion\u2010associated circulatory overload (<jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>) include the use of diuretics. The purpose of this study was to determine how commonly diuretics are prescribed in patients receiving a red\u2010blood\u2010cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This was a retrospective study of 200 adult inpatient <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion orders, 50 consecutive at each of four academic institutions. Only the first transfusion order for each patient was included. Only 1 or 2 unit orders were included. The primary outcome was the percentage of patients receiving furosemide peri\u2010transfusion. Secondary objectives included the dose, route, and timing of furosemide and the association of clinical factors with ordering furosemide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 62\u00b75 years (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 53, 73), and 52% were female. Peri\u2010transfusion furosemide was ordered in 16% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 11\u201321%). The most common dose was 20 mg (55%), the route intravenous (90%) and timing post\u2010transfusion (74%). At least one risk factor for <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> was present in 55% of patients: renal dysfunction (33%), older than 70 years (28%), history of congestive heart failure (18%), ejection fraction &lt;60% (16%) and diastolic dysfunction (5%). Low haemoglobin as an indication for transfusion (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4\u00b72; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b74\u201312\u00b78) and diuretics on admission (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3\u00b75; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b75\u20138\u00b70) were associated with ordering furosemide peri\u2010transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Furosemide is not routinely ordered for <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion, even in patients with risk factors for <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content>. Studies assessing the safety, efficacy, optimal dose, and timing of furosemide in preventing <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> are justified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12647","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T05:43:48Z","timestamp":1520487828000},"page":"386-392","source":"Crossref","is-referenced-by-count":9,"title":["Transfusion\u2010associated circulatory overload prevention: a retrospective observational study of diuretic use"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-9020","authenticated-orcid":false,"given":"Y.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Armali","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Callum","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pendergrast","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"University of Toronto QUEST Research Program Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"U.S. Food and Drug Administration:Fatalities reported to FDA following blood collection and transfusion: annual summary for fiscal year 2015.http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/SafetyAvailability\/ReportaProblem\/TransfusionDonationFatalities\/UCM518148.pdf 2015 [Last accessed 14 October 2016]"},{"key":"e_1_2_7_3_1","unstructured":"Public Health Agency of Canada:Health Canada transfusion transmitted injuries surveillance system 2006 \u2013 2012 report.http:\/\/www.phac-aspc.gc.ca\/hcai-iamss\/ttiss-ssit\/index-eng.php 2014 [Last accessed 15 January 2016]"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12257"},{"key":"e_1_2_7_5_1","unstructured":"Bolton\u2010MaggsPE PolesD On behalf of the Serious Hazards of Transfusion (SHOT) Steering Group et al.:The 2016 annual SHOT report. Manchester 2017.https:\/\/www.shotuk.org\/wp-content\/uploads\/SHOT-Report-2016_web_11th-July.pdf[Last accessed 15 December 2017]"},{"key":"e_1_2_7_6_1","volume-title":"Ontario Transfusion Transmitted Injuries Surveillance System (TTISS) Program Report: 2012 \u20102016","author":"McMaster Transfusion Research Program","year":"2017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000513"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00930.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12466"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.07.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.02.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.019"},{"issue":"2","key":"e_1_2_7_13_1","first-page":"CD010138","article-title":"Loop diuretics for patients receiving blood transfusions","author":"Sarai M","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_14_1","unstructured":"AABB:Association bulletin #15\u201002: transfusion associated circulatory overload 2015.http:\/\/www.aabb.org\/programs\/publications\/bulletins\/Docs\/ab15-02.pdf[Last accessed 29 December 2017]"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13737"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02636.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12284"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23238"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978303401102"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6186.360"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2011.01.006"},{"key":"e_1_2_7_22_1","unstructured":"CallumJ:Pre\u2010transfusion furosemide in patients at high risk of transfusion\u2010associated circulatory overload \u2010 the Transfusion\u2010Associated Circulatory Overload Best Eliminated With Lasix (TACO\u2010BEL) study: a pilot randomized controlled trial. 2017.https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02802696?cond=TACO&rank=1[Last accessed 29 December 2017]"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:26:46Z","timestamp":1695515206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/vox.12647"],"URL":"https:\/\/doi.org\/10.1111\/vox.12647","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}