{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:38:24Z","timestamp":1788514704069,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"International Society of Blood Transfusion (ISBT)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p><jats:italic>Babesia<\/jats:italic> spp. are tick\u2010borne, intraerythrocytic protozoan parasites, several of which are transfusion\u2010transmissible. Transfusion\u2010transmitted babesiosis poses serious risk to a diverse patient population, including neonates, patients aged &gt;50 years, the asplenic and the immunocompromised that are over\u2010represented among transfusion recipients. Despite reports of <jats:italic>B. microti<\/jats:italic> and <jats:italic>B. venatorum<\/jats:italic> in People's Republic of China (<jats:styled-content style=\"fixed-case\">PRC<\/jats:styled-content>), no surveillance of blood donors for <jats:italic>Babesia<\/jats:italic> has previously been undertaken. We sought to determine the rates of <jats:italic>B. microti<\/jats:italic> seroreactivity in a sample of blood donors in the <jats:styled-content style=\"fixed-case\">PRC<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A pilot serosurvey was conducted of community blood donors (<jats:italic>n<\/jats:italic> = 1000) who donated July\u2013August 2016 at Mudanjiang Blood Center (Heilongjiang Province) using indirect fluorescent antibody testing for antibodies against <jats:italic>B. microti<\/jats:italic>. The slides were prepared using <jats:italic>B. microti<\/jats:italic>\u2010infected hamster blood. Samples that were initially positive to a titre of 64 were subjected to repeat <jats:styled-content style=\"fixed-case\">IFA<\/jats:styled-content> testing. Final seroreactivity was based on repeat reactivity to \u226564.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1000 individual donor samples were evaluated, comprising 888 whole blood and 112 platelet donations. Thirteen of 1000 (1\u00b73%) donors were seroreactive for <jats:italic>B. microti<\/jats:italic> [8 (0\u00b78%) and five (0\u00b705%) at titres of 64 and 128, respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our preliminary findings support the need for expanded Babesia surveillance in Chinese blood donors, replete with molecular evaluation, to evaluate the risk to the blood supply.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12648","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T02:15:43Z","timestamp":1522116943000},"page":"345-349","source":"Crossref","is-referenced-by-count":15,"title":["A pilot serosurvey of <i>Babesia microti<\/i> in Chinese blood donors"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9517","authenticated-orcid":false,"given":"E. M.","family":"Bloch","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tonnetti","sequence":"additional","affiliation":[{"name":"American Red Cross Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Guo","sequence":"additional","affiliation":[{"name":"Mudanjiang blood center Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Li","sequence":"additional","affiliation":[{"name":"Mudanjiang blood center Heilongjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Leiby","sequence":"additional","affiliation":[{"name":"United States Food and Drug Administration Silver Spring MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Shan","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ISBT TTID Working Party Parasite Subgroup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807163390304"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.04.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1202018"},{"key":"e_1_2_7_5_1","first-page":"1","volume-title":"Parasitic Protozoa: Babesia and Plasmodia","author":"Telford SRI","year":"1993"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.3.451-469.2000"},{"key":"e_1_2_7_7_1","first-page":"509","article-title":"Human babesiosis, an emerging tick\u2010borne disease in the People's Republic of China","volume":"7","author":"Zhou X","year":"2014","journal-title":"Parasit Vectors"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/emi.2014.55"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-016-0121-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.6.2178-2183.2001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01334-06"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2014.52.4.443"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03948.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00177-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02430.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-8-201110180-00362"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71046-1"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T00:26:48Z","timestamp":1695515208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/vox.12648"],"URL":"https:\/\/doi.org\/10.1111\/vox.12648","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]}}}