{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:28:40Z","timestamp":1783722520703,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","award":["DJCLS R 12\/34"],"award-info":[{"award-number":["DJCLS R 12\/34"]}],"id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objective<\/jats:title>\n                    <jats:p>Extracorporeal photopheresis (ECP) is an important immune tolerance inducing therapy for graft\u2010versus\u2010host disease (GvHD). However, a sufficient number of ECP cycles cannot be performed in patients with severe GvHD and contraindications for apheresis. Allogeneic sources of leucocytes for use as ECP treatment would be of great benefit. Therefore, this study aimed to test the therapeutic potential of novel sources of leucocytes for ECP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Graft\u2010versus\u2010host disease mice were treated with ECP using therapeutic cells from different allogeneic sources. Splenocytes were incubated with 8\u2010methoxypsoralen (8\u2010MOP), irradiated with UVA light and injected into GvHD mice as a model for ECP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The therapy with 8\u2010MOP\/UVA\u2010treated cells from healthy mice of the bone marrow transplantation (BMT) donor strain reduced the GvHD symptoms, at least in a model of chronic GvHD. In the acute GvHD model, 8\u2010MOP\/UVA\u2010treated cells from the BMT donor or recipient strain did not show significant improvements in GvHD symptoms or survival time. Pre\u2010activation of cells by mixed lymphocyte reactions before 8\u2010MOP\/UVA treatment also failed to result in significant differences in survival time or GvHD score. In contrast, ECP with third\u2010party 8\u2010MOP\/UVA\u2010treated cells from a HLA\u2010mismatched donor resulted in a mean survival time of 37 days compared to 21 days in the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our analysis of novel allogeneic leucocyte sources for ECP, we could demonstrate that the source of the 8\u2010MOP\/UVA\u2010treated cells is crucial. The underlying immunologic effect of allogeneic 8\u2010MOP\/UVA\u2010treated cells needs to be investigated in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.12723","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:05:38Z","timestamp":1540343138000},"page":"803-810","source":"Crossref","is-referenced-by-count":5,"title":["An alternative for extracorporeal photopheresis: 8\u2010methoxypsoralen and UVA\u2010treated leucocytes from allogeneic donors improve graft\u2010versus\u2010host disease in mice"],"prefix":"10.1111","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5133-1166","authenticated-orcid":false,"given":"Holger","family":"Budde","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Papert","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger M.","family":"Reichardt","sequence":"additional","affiliation":[{"name":"Institute for Cellular and Molecular Immunology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Jarry","sequence":"additional","affiliation":[{"name":"Department of Experimental Endocrinology University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Riggert","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias J.","family":"Legler","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine University Medical Center G\u00f6ttingen G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-0329"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32832ce943"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70257-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.271"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.174"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12311"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12596"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21455"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03013.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21354"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc0511"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/ceji.2017.67312","article-title":"In 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