{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:24:11Z","timestamp":1787016251831,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>\n                      In Caucasians, fetal\/neonatal alloimmune thrombocytopenia (\n                      <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>\n                      ) is most commonly due to maternal\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a antibodies.\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a typing followed by screening for anti\u2010\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a antibodies in\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101bb women may identify first pregnancies at risk. Our goal was to review results from previous published studies to examine whether the maternal antibody level to\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a could be used to identify high\u2010risk pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The studies included were categorized by recruitment strategies: screening of unselected pregnancies or samples analyzed from known or suspected\n                      <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>\n                      patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Three prospective studies reported results from screening programmes, and 10 retrospective studies focused on suspected cases of\n                      <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>\n                      . In 8 studies samples for antibody measurement, performed by the monoclonal antibody immobilization of platelet antigen (\n                      <jats:styled-content style=\"fixed-case\">MAIPA<\/jats:styled-content>\n                      ) assay, and samples for determining fetal\/neonatal platelet count were collected simultaneously. In these 8 studies, the maternal antibody level correlated with the risk of severe thrombocytopenia. The prospective studies reported high negative predictive values (88\u201395%), which would allow for the use of maternal anti\u2010\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a antibody level as a predictive tool in a screening setting, in order to identify cases at low risk for\n                      <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>\n                      . However, due to low positive predictive values reported in prospective as well as retrospective studies (54\u201397%), the maternal antibody level is less suited for the final diagnosis and for guiding antenatal treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\n                      \u20101a antibody level has the potential to predict the severity of\n                      <jats:styled-content style=\"fixed-case\">FNAIT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.12725","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T09:55:27Z","timestamp":1545213327000},"page":"79-94","source":"Crossref","is-referenced-by-count":49,"title":["Maternal\n                    <scp>HPA<\/scp>\n                    \u20101a antibody level and its role in predicting the severity of Fetal\/Neonatal Alloimmune Thrombocytopenia: a systematic review"],"prefix":"10.1111","volume":"114","author":[{"given":"Mette","family":"Kj\u00e6r","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Diagnostic Clinic University Hospital of North Norway Troms\u00f8 Norway"},{"name":"Finnmark Hospital Trust Finnmark Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Platelet Immunology Department French Blood Services of Brittany Rennes 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