{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:09:43Z","timestamp":1789697383484,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NSW Health Pathology North Hunter Trust Funds","award":["1\/2017"],"award-info":[{"award-number":["1\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload is a leading cause of transfusion\u2010related adverse events. The frequency and risks for transfusion\u2010associated circulatory overload in ambulatory haematology patients are not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A retrospective cohort analysis of ambulatory patients transfused in a tertiary haematology centre, using medical records and an electronic transfusion database, was undertaken between January and December 2014. Variables studied included age, gender, diagnosis, heart failure, kidney disease and details of transfusions. Transfusion\u2010associated circulatory overload was defined according to proposed International Society of Blood Transfusion criteria. Patients with clinical evidence of hypervolaemia, not meeting the <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> definition and\/or who were prescribed otherwise unscheduled diuretic agent, were collectively deemed to be at \u2018risk of clinically significant hypervolaemia\u2019 (<jats:styled-content style=\"fixed-case\">ROCSH<\/jats:styled-content>)<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study period, 93 ambulatory patients (male\u00a0=\u00a049, female\u00a0=\u00a044, mean age\u00a0=\u00a075\u00b789\u00a0\u00b1\u00a011\u00b737\u00a0years) attended 715 transfusion encounters, totalling 1536 packed red cell units. No cases of <jats:styled-content style=\"fixed-case\">TACO<\/jats:styled-content> occurred whilst \u2018<jats:styled-content style=\"fixed-case\">ROCSH<\/jats:styled-content>\u2019 events occurred in 57\/715 (8%) of transfusion encounters. In a univariate model, age was significantly associated with \u2018<jats:styled-content style=\"fixed-case\">ROCSH<\/jats:styled-content>\u2019, odds ratio\u00a0=\u00a01\u00b705 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017 95%, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b701\u20131\u00b709) and no factors were significant on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload occurs infrequently haematology patients receiving ambulatory blood transfusions. To our knowledge, this is the first study to report on occurrence and risk factors for circulatory overload in ambulatory transfusions. This study provides vital baseline data for future prospective studies on this important aspect of haemovigilance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12753","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T07:08:38Z","timestamp":1549609718000},"page":"216-222","source":"Crossref","is-referenced-by-count":4,"title":["Transfusion\u2010associated circulatory overload in ambulatory patients"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-1732","authenticated-orcid":false,"given":"Jock D.","family":"Simpson","sequence":"first","affiliation":[{"name":"Haematology Department Calvary Mater Newcastle Waratah NSW Australia"},{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Hopkins","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilah","family":"Amil","sequence":"additional","affiliation":[{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryony","family":"Ross","sequence":"additional","affiliation":[{"name":"Haematology Department Calvary Mater Newcastle Waratah NSW Australia"},{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"},{"name":"NSW Health Pathology \u2010 Hunter New Lambton Heights NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-090X","authenticated-orcid":false,"given":"Anoop K.","family":"Enjeti","sequence":"additional","affiliation":[{"name":"Haematology Department Calvary Mater Newcastle Waratah NSW Australia"},{"name":"School of Medicine and Public Health University of Newcastle Callaghan NSW Australia"},{"name":"NSW Health Pathology \u2010 Hunter New Lambton Heights NSW Australia"},{"name":"Hunter Medical Research Institute New Lambton NSW Australia"},{"name":"Hunter Cancer Research Alliance Callaghan NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12380"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12447"},{"key":"e_1_2_7_4_1","unstructured":"Fatalities reported to the FDA following blood collection and transfusion: annual summary for fiscal year 2012. Online U.S. Food and Drug Administration 2014.https:\/\/www.fda.gov\/BiologicsBloodVaccines\/SafetyAvailability\/ReportaProblem\/TransfusionDonationFatalities\/ucm346639.htm(Last accessed."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12547"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12454"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.02.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.07.002"},{"issue":"357","key":"e_1_2_7_9_1","first-page":"e29","article-title":"Risk factors and outcomes in transfusion\u2010associated circulatory overload","volume":"126","author":"Murphy EL","year":"2013","journal-title":"Am J Med"},{"key":"e_1_2_7_10_1","unstructured":"International Society of Blood Transfusion Proposed standard definitions for surveillance of non infectious adverse transfusion reactions. International Haemovigilance Network 2011.http:\/\/www.ihn-org.com\/wp-content\/uploads\/2011\/06\/ISBT-definitions-for-non-infectious-transfusion-reactions.pdf(Last accessed 2\/8\/2017 2017)."},{"key":"e_1_2_7_11_1","unstructured":"Transfusion\u2010associated circulatory overload (TACO) Drafted revised reporting criteria. International Society of Blood Transfusion The International Haemovigilance Network.http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/Working_parties\/WP_on_Haemovigilance\/TACO_reporting_criteria_draft_Nov_2016.pdf(Last accessed 22\/7\/2017 2017)."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/2007-131-708-NCOBT"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13730"},{"key":"e_1_2_7_15_1","first-page":"137","article-title":"Transfusion\u2010associated circulatory overload in adult, medical emergency patients with perspectives on early warning practice: a single\u2010centre, clinical study","volume":"16","author":"Gosmann F","year":"2018","journal-title":"Blood Transfus"},{"key":"e_1_2_7_16_1","unstructured":"BachowskiG BorgeD BrunkerP et\u00a0al.:A Compendium of Transfusion Practice Guidelines Third Edition 2017. American Association Blood Banks 2017.http:\/\/success.redcross.org\/success\/file.php\/1\/TransfusionPractices-Compendium_3rdEdition.pdf(Last accessed 22\/07\/2017 2017)."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12466"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001506"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12965"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02816.x"},{"key":"e_1_2_7_21_1","volume-title":"Clinical examination: a systematic guide to physical diagnosis","author":"Tally N","year":"2010"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.12753","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:21:18Z","timestamp":1694380878000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/vox.12753"],"URL":"https:\/\/doi.org\/10.1111\/vox.12753","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]}}}