{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:49:25Z","timestamp":1790696965613,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL133024"],"award-info":[{"award-number":["R01 HL133024"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background And Objectives<\/jats:title><jats:p>Alloimmunization is common following transfusion with platelet\u2010rich plasma (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) and can cause complications such as platelet refractoriness or transplant rejection. It has previously been shown that pathogen reduction of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> with riboflavin and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light (<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>+R) can protect against alloimmunization in mice and induce partial tolerance to subsequent transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Using B6 H2<jats:sup>d<\/jats:sup> congenic mice, this study evaluated the relative contributions of major histocompatibility complex (<jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>) antigens and minor antigens to both the alloresponse to <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> transfusion and the partial tolerance induced by <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>+R treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both total and <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>\u2010specific alloantibody responses were highest when both <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> and minor antigens were mismatched, with lower alloantibody responses observed with <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> mismatch alone, demonstrating that allogeneic minor antigens can enhance the response to allogeneic <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content>. There was a weak, but significant alloantibody response to minor antigens only. <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>+R treatment protected against both major and minor antigen alloimmunization. Both allogeneic <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> and minor antigens primed an enhanced cytokine response <jats:italic>ex\u00a0vivo<\/jats:italic>, though this was weaker with minor antigens, and both responses were blocked with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>+R treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Allogeneic <jats:styled-content style=\"fixed-case\">MHC<\/jats:styled-content> is both necessary and sufficient to induce the partial tolerance associated with <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>+R treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12756","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T06:47:26Z","timestamp":1549608446000},"page":"207-215","source":"Crossref","is-referenced-by-count":10,"title":["Allogeneic major histocompatibility complex antigens are necessary and sufficient for partial tolerance induced by transfusion of pathogen reduced platelets in mice"],"prefix":"10.1111","volume":"114","author":[{"given":"Johnson Q.","family":"Tran","sequence":"first","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8946-6605","authenticated-orcid":false,"given":"Marcus O.","family":"Muench","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"},{"name":"University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Heitman","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8591-7819","authenticated-orcid":false,"given":"Rachael P.","family":"Jackman","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"},{"name":"University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1978.18478251250.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.8.786"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.3.964.bloodjournal723964"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.3.395.bloodjournal573395"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1985.tb00807.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000115399.80913.B1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02965.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V62.4.815.bloodjournal624815"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V77.1.201.201"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12317"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30790385520.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060766.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060771.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41060762.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.3.824.bloodjournal853824"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12133"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-726901"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13579"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02333.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00777.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21166"},{"issue":"2","key":"e_1_2_7_24_1","first-page":"197","article-title":"Extracorporeal photochemotherapy\u2013present and future","volume":"78","author":"Knobler R","year":"2000","journal-title":"Vox Sang"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1054\/blre.2001.0155"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.11.4375.4375"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.4.1239"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14534"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13895"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aam6202"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010124"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1998.tb01007.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.7.1736.bloodjournal8571736"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(96)80108-7"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-9994-2-16"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28689059040.x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41080984.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V73.2.606.606"},{"key":"e_1_2_7_39_1","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1182\/blood.V68.6.1363.1363","article-title":"Decreased incidence of marrow graft rejection in patients with severe aplastic anemia: changing impact of risk factors","volume":"68","author":"Deeg HJ","year":"1986","journal-title":"Blood"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.1.269.269"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39590"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12756","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.12756","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12756","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:21:24Z","timestamp":1694380884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/vox.12756"],"URL":"https:\/\/doi.org\/10.1111\/vox.12756","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]}}}