{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:28:53Z","timestamp":1792794533370,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T00:00:00Z","timestamp":1550534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transmission of pathogens through blood transfusion is still of great concern to clinicians, patients and blood providers. Pathogen reduction technologies (<jats:styled-content style=\"fixed-case\">PRT<\/jats:styled-content>) have been successfully applied for the treatment of labile blood components, such as plasma, platelets and whole blood (<jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>), which are now used in routine in many countries. We report the clinical evaluation of suspension of red blood cells (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S) derived from the <jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content> treated with riboflavin and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> light (<jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>Seventy paediatric patients (0\u00b73\u201317\u00b71\u00a0years old) suffering from different malignant disorders were recruited and assigned to two groups: the control group (C) received transfusions of \u03b3\u2010irradiated <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S. The experimental group (T) received <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S derived from <jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>, treated with <jats:styled-content style=\"fixed-case\">RF<\/jats:styled-content>+<jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>. Clinical efficacy was evaluated during follow\u2010up periods by Hb and Ht increments, and needs for transfusion support. Safety was assessed through active surveillance, recording post\u2010transfusion reactions, anti\u2010erythrocyte's antibody formation, haptoglobin and serum potassium levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical efficacy of <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S in both groups was similar: mean post\u2010transfusion Hb concentration (101\u00b76\u00a0\u00b1\u00a07\u00b757\u00a0g\/l vs. 100\u00a0\u00b1\u00a08\u00b73\u00a0g\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b743), and Ht level (28\u00b75\u00a0\u00b1\u00a02\u00b742% vs. 28\u00b72\u00a0\u00b1\u00a02\u00b77%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b766). Transfusion of pathogen\u2010reduced <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S did not increase the frequency of transfusion reactions and did not induce an excessive immune response in the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion of <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>\u2010S, obtained from pathogen\u2010reduced <jats:styled-content style=\"fixed-case\">WB<\/jats:styled-content>, is a promising method to increase the safety of blood component therapy for paediatric patients with malignant disorders without affecting clinical efficacy. A randomized clinical trial including more patients should follow this pilot study to confirm its results.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12757","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T02:39:55Z","timestamp":1550630395000},"page":"223-231","source":"Crossref","is-referenced-by-count":21,"title":["The pathogen\u2010reduced red blood cell suspension: single centre study of clinical safety and efficacy in children with oncological and haematological diseases"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0231-1617","authenticated-orcid":false,"given":"Pavel","family":"Trakhtman","sequence":"first","affiliation":[{"name":"National Medical Research Center for Pediatric Hematology, Oncology and Immunology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-1041","authenticated-orcid":false,"given":"Irina","family":"Kumukova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Pediatric Hematology, Oncology and Immunology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1219-8654","authenticated-orcid":false,"given":"Nikolay","family":"Starostin","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Pediatric Hematology, Oncology and Immunology Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4669-977X","authenticated-orcid":false,"given":"Daria","family":"Borsakova","sequence":"additional","affiliation":[{"name":"National Medical Research Center for Pediatric Hematology, Oncology and Immunology Moscow Russia"},{"name":"Laboratory of Physiology and 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