{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:18:57Z","timestamp":1778901537320,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J012483\/1"],"award-info":[{"award-number":["MR\/J012483\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Paediatric blood transfusion for severe anaemia in hospitals in sub\u2010Saharan Africa remains common. Yet, reports describing the haematological quality of donor blood or storage duration in routine practice are very limited. Both factors are likely to affect transfusion outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We undertook three audits examining the distribution of pack types, haematological quality and storage duration of donor blood used in a paediatric clinical trial of blood at four hospitals in Africa (Uganda and Malawi).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall distribution of whole blood, packed cells (plasma\u2010reduced by centrifugation) and red cell concentrates (<jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content>) (plasma\u2010reduced by gravity\u2010dependent sedimentation) used in a randomised trial was 40\u00b77% (<jats:italic>N<\/jats:italic>\u00a0=\u00a01215), 22\u00b74% (<jats:italic>N<\/jats:italic>\u00a0=\u00a0669) and 36\u00b78% (<jats:italic>N<\/jats:italic>\u00a0=\u00a01099), respectively. The first audit found similar median haematocrits of 57\u00b70% (50\u00b70,74\u00b70), 64\u00b70% (52\u00b70,72\u00b75; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7238 vs. whole blood) and 56\u00b70% (48\u00b70,67\u00b70; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7462) in whole blood, <jats:styled-content style=\"fixed-case\">RCC<\/jats:styled-content> and packed cells, respectively, which resulted from unclear pack labelling by blood transfusion services (<jats:styled-content style=\"fixed-case\">BTS<\/jats:styled-content>). Re\u2010training of the <jats:styled-content style=\"fixed-case\">BTS<\/jats:styled-content>, hospital blood banks and clinical teams led to, in subsequent audits, significant differences in median haematocrit and haemoglobins across the three pack types and values within expected ranges. Median storage duration time was 12\u00a0days (<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>: 6, 19) with 18\u00b72% (537\/2964) over 21\u00a0days in storage. Initially, 9 (2\u00b78%) packs were issued past the recommended duration of storage, dropping to 0\u00b73% (<jats:italic>N<\/jats:italic>\u00a0=\u00a07) in the third audit post\u2010training.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study highlights the importance of close interactions and education between <jats:styled-content style=\"fixed-case\">BTS<\/jats:styled-content> and clinical services and the importance of haemovigilance to ensure safe transfusion practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12764","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T05:07:49Z","timestamp":1551848869000},"page":"340-348","source":"Crossref","is-referenced-by-count":14,"title":["Haematological quality and age of donor blood issued for paediatric transfusion to four hospitals in sub\u2010Saharan Africa"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-7873","authenticated-orcid":false,"given":"Sophie","family":"Uyoga","sequence":"first","affiliation":[{"name":"KEMRI\/Wellcome Trust Research Programme Kilifi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayub","family":"Mpoya","sequence":"additional","affiliation":[{"name":"KEMRI\/Wellcome Trust Research Programme Kilifi Kenya"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Olupot\u2010Olupot","sequence":"additional","affiliation":[{"name":"Mbale Clinical Research Institute Mbale Uganda"},{"name":"Faculty of Health Sciences Busitema University, Mbale Campus Mbale Ugandas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kiguli","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Mulago Hospital Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert O.","family":"Opoka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Mulago Hospital Makerere University Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Engoru","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Soroti Regional Referral Hospital Soroti Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macpherson","family":"Mallewa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health College of Medicine University of Malawi Blantyre Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health College of Medicine University of Malawi Blantyre Malawi"},{"name":"School of Medicine Dentistry and Biomedical Science Queen's University Belfast UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bridon","family":"M'baya","sequence":"additional","affiliation":[{"name":"Malawi Blood Transfusion Service Blantyre Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Kyeyune","sequence":"additional","affiliation":[{"name":"Uganda Blood Transfusion Service Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Wabwire","sequence":"additional","affiliation":[{"name":"Mbale Regional Blood Bank Mbale Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imelda","family":"Bates","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine and Hygiene Pembroke Place Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana M.","family":"Gibb","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit Institute of Clinical Trials &amp; 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