{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:08:33Z","timestamp":1789697313512,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The role of pre\u2010donation blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) as independent contributor to post\u2010donation vasovagal reactions (<jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s) is still debated. Differences between a liberal (i.e., inclusion of hypotensive donors) and a restrictive policy (i.e., not accepting hypotensive donors) should be investigated. This study aims to investigate the consequences of a liberal policy in development of <jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s after whole\u2010blood donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We compared the incidence of <jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s between 2015 (restrictive policy) and 2016 (liberal policy) and the associated risk factors. We evaluated respectively 22\u00a0789 vs. 21\u00a0676 blood donations obtained from 18\u00a0001 blood donors (12\u00a0501 donated in both years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparing the results we obtained between 2015 and 2016, donations showed an overlap of the cohorts. Two hundred fifteen <jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s (incidence rate 0\u00b748%) were observed, 104 (0\u00b746%) of which in 2015, and 111 (0\u00b751%) in 2016. A preliminary univariate analysis showed that donors with systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> &lt;110\u00a0mm\u00a0Hg had a two\u2010fold risk of <jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s compared to normotensive donors (<jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>\/donation rate of 0\u00b799% vs. 0\u00b746%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). The subsequent multivariable logistic regression model showed that <jats:styled-content style=\"fixed-case\">VVR<\/jats:styled-content>s were highly associated with weight, site of collection, age and number of donations, excluding a role for systolic and diastolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A liberal pre\u2010donation <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> policy seems to be safe for blood donors. Our analysis confirms that older donors with higher body\u2010weight who already had donated blood are unlikely to experience <jats:styled-content style=\"fixed-case\">VVRs<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12772","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T05:27:36Z","timestamp":1552973256000},"page":"317-324","source":"Crossref","is-referenced-by-count":4,"title":["Effect of a liberal versus a restrictive pre\u2010donation blood pressure policy on whole\u2010blood donor adverse reactions"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-5566","authenticated-orcid":false,"given":"Ugo","family":"Salvadori","sequence":"first","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Sandri","sequence":"additional","affiliation":[{"name":"DMS StatLab University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cemin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al\u2010Khaffaf","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Daves","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Hueber","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Troi","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid","family":"Griessmair","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Ploner","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Egger","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gottfried","family":"Kuehebacher","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Gentilini","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Vecchiato","sequence":"additional","affiliation":[{"name":"Department of Immunohaematology and Transfusion Central Hospital of Bolzano Bolzano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2011.09.003"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20257"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2014.03.332"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.003"},{"key":"e_1_2_5_6_1","volume-title":"Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation","author":"World Health Organization","year":"2012"},{"key":"e_1_2_5_7_1","volume-title":"Guide to the Preparation, Use and Quality Assurance of Blood Components","author":"Council of Europe","year":"2017"},{"key":"e_1_2_5_8_1","unstructured":"DECRETO 2 novembre 2015 Disposizioni relative ai requisiti di qualita\u2019 e sicurezza del sangue e degli emocomponenti. 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