{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:42:36Z","timestamp":1790048556478,"version":"4.0.1"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Human T\u2010cell lymphotropic viruses (<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>) 1 and\u00a02 are endemic in sub\u2010Saharan Africa (<jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content>), transfusion\u2010transmissible and causally linked to various severe diseases. However, even in <jats:styled-content style=\"fixed-case\">SSA<\/jats:styled-content> countries with moderate to high endemicity, routine blood donor screening for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content> is rarely, if ever, performed. Information on seroprevalence is limited.\u00a0The aim of this review is to establish the prevalence of <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 and\u00a0<jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101\/2 among blood donors in sub\u2010Saharan Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We systematically reviewed databases including <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> MEDLINE<\/jats:styled-content> and the Cochrane database library from their inception to June 2018. Studies presenting data on <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content> prevalence among blood donors in sub\u2010Saharan Africa were included. A random\u2010effect meta\u2010analysis was conducted on all eligible studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25 studies were included, representing 74\u00a0119 blood donors, of whom over 80% (61\u00a0002) were only tested for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101. The evidence base was high and moderate in quality. The pooled prevalence of the 17 studies that screened only for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 and the nine studies that screened for <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101\/2 was 0\u00b768 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b729\u20131\u00b760) and 1\u00b711 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0\u00b747\u20132\u00b759) per 100 blood donors, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content>\u20101 infection among blood donors is relatively low. The current review is intended to inform debates and decisions about best practices to prevent transfusion\u2010transmitted <jats:styled-content style=\"fixed-case\">HTLV<\/jats:styled-content> in sub\u2010Saharan Africa. Further work is required to determine the risk of infections by transfusion and the cost\u2010effectiveness of any new measures such as routine screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12779","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:56:46Z","timestamp":1555030606000},"page":"413-425","source":"Crossref","is-referenced-by-count":19,"title":["Seroprevalence of human T\u2010lymphotropic virus (<scp>HTLV<\/scp>) in blood donors in sub\u2010Saharan Africa: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-7281","authenticated-orcid":false,"given":"Alain M.","family":"Ngoma","sequence":"first","affiliation":[{"name":"Douglas Hospital Research Centre McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magot D.","family":"Omokoko","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Cit\u00e9\u2010de\u2010la\u2010Sant\u00e9 Affiliated to the University of Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulin B.","family":"Mutombo","sequence":"additional","affiliation":[{"name":"School of Public Health University of Kinshasa Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Nollet","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan"},{"name":"Radiation Medical Science Center Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0340-883X","authenticated-orcid":false,"given":"Hitoshi","family":"Ohto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan"},{"name":"Radiation Medical Science Center Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,11]]},"reference":[{"issue":"3","key":"e_1_2_6_2_1","first-page":"388","article-title":"Epidemiological aspects and world distribution of HTLV\u20101 infection","volume":"15","author":"Gessain A","year":"2012","journal-title":"Front Microbiol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01425"},{"issue":"29","key":"e_1_2_6_4_1","first-page":"2233","article-title":"A virus called HTLV\u20101. 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