{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:08:30Z","timestamp":1747188510752,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T00:00:00Z","timestamp":1562284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The perception of transfusion\u2010transmitted infections (TTIs) is sensitive to various concerns besides the probability and impact of infection, and some of these concerns may be ethically relevant. This paper aims to advance thinking about blood safety policies by exploring and explaining stakeholders\u2019 reasons to consider TTI risks tolerable or intolerable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Inspired by critical empirical ethics and phenomenological hermeneutics, we held interviews and focus group discussions to explore the moral experience of policymakers, hematologists, blood donors and recipients. Respondents were invited to discuss general concerns about the blood supply, to address the tolerability of TTI risks compared with other hazards and to comment on the costs of blood safety. Arguments for tolerance or intolerance towards TTI risks were analysed qualitatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stakeholders\u2019 views could be clustered into seven categories: (1) clinical impact; (2) probability of infection; (3) avoidability of infection; (4) cost and health benefits; (5) other consequences of safety measures; (6) non\u2010consequentialist ethical arguments; and (7) stakeholders\u2019 interests. Various arguments were offered that resonate with current ethical thinking about blood safety. Assuming that resources spent on inefficient blood safety measures could be applied more beneficially elsewhere, for example, responders typically expressed tolerance towards TTI risks. Some other arguments seem novel, for instance arguments for risk intolerance based on the low probability of infection and arguments for risk tolerance if patients have a poor prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Understanding the moral experience of stakeholders enriches ethical debate about blood safety and prepares developing more widely acceptable policies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12821","type":"journal-article","created":{"date-parts":[[2019,7,5]],"date-time":"2019-07-05T07:36:00Z","timestamp":1562312160000},"page":"658-665","source":"Crossref","is-referenced-by-count":3,"title":["When are infection risks of blood transfusion tolerable? Towards understanding the ethical views of stakeholders in the blood supply"],"prefix":"10.1111","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7135-6691","authenticated-orcid":false,"given":"Koen","family":"Kramer","sequence":"first","affiliation":[{"name":"Department of Blood\u2010borne Infections (BOI) Sanquin Blood Supply Foundation Amsterdam The Netherlands"},{"name":"Department of Communication, Philosophy and Technology (CPT) Wageningen University and Research Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-1852","authenticated-orcid":false,"given":"Marcel F.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Communication, Philosophy and Technology (CPT) Wageningen University and Research Wageningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0773-7315","authenticated-orcid":false,"given":"Hans L.","family":"Zaaijer","sequence":"additional","affiliation":[{"name":"Department of Blood\u2010borne Infections (BOI) Sanquin Blood Supply Foundation Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03319.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02877.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00392.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00198.x"},{"key":"e_1_2_8_6_1","unstructured":"Alliance of Blood Operators: Risk\u2010based decision\u2010making framework for blood safety.2015. 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