{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:31:55Z","timestamp":1792593115202,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Patient Blood Management (PBM) is the timely application of evidence\u2010based medical and surgical concepts designed to improve haemoglobin concentration, optimize haemostasis and minimize blood loss in an effort to improve patient outcomes. The focus of this cost\u2010benefit analysis is to analyse the economic benefit of widespread implementation of a multimodal PBM programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Based on a recent meta\u2010analysis including 17 studies (&gt;235\u00a0000 patients) comparing PBM with control care and data from the University Hospital Frankfurt, a cost\u2010benefit analysis was performed. Outcome data were red blood cell (RBC) transfusion rate, number of transfused RBC units, and length of hospital stay (LOS). Costs were considered for the following three PBM interventions as examples: anaemia management including therapy of iron deficiency, use of cell salvage and tranexamic acid. For sensitivity analysis, a Monte Carlo simulation was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Iron supplementation was applied in 3\u00b71%, cell salvage in 65% and tranexamic acid in 89% of the PBM patients. In total, applying these three PBM interventions costs \u20ac129\u00b704 per patient. However, PBM was associated with a reduction in transfusion rate, transfused RBC units per patient, and LOS which yielded to mean savings of \u20ac150\u00b764 per patient. Thus, the overall benefit of PBM implementation was \u20ac21\u00b760 per patient. In the Monte Carlo simulation, the cost savings on the outcome side exceeded the PBM costs in approximately 2\/3 of all repetitions and the total benefit was \u20ac1\u00a0878\u00a0000 in 100\u00b7000 simulated patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Resources to implement a multimodal PBM concept optimizing patient care and safety can be cost\u2010effectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.12873","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T23:04:56Z","timestamp":1576019096000},"page":"182-188","source":"Crossref","is-referenced-by-count":38,"title":["Health economics of Patient Blood Management: a cost\u2010benefit analysis based on a meta\u2010analysis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2666-8696","authenticated-orcid":false,"given":"Patrick","family":"Meybohm","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"},{"name":"Department of Anaesthesiology University Hospital Wuerzburg Wuerzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Straub","sequence":"additional","affiliation":[{"name":"Institute of Market Research, Statistics and Prognosis Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"F\u00fcllenbach","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Judd","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adina","family":"Kleiner\u00fcschkamp","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy Helios University Hospital Wuppertal Wuppertal Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Taeuber","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-9110","authenticated-orcid":false,"given":"Kai","family":"Zacharowski","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suma","family":"Choorapoikayil","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Intensive Care Medicine and Pain Therapy University Hospital Frankfurt, Goethe University Frankfurt Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.WHO Global Forum for Blood Safety: Patient blood management.2011;https:\/\/www.who.int\/bloodsafety\/events\/gfbs_01_pbm\/en\/. 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