{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:41:51Z","timestamp":1787953311904,"version":"build-2784847793"},"reference-count":100,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The local prevalence of HPgV\u20101 has been reported from different countries worldwide, but the global prevalence of HPgV\u20101 remains unknown. The aim of this systematic review and meta\u2010analysis was to gather data from the literature to estimate the prevalence of HPgV\u20101 in healthy volunteer blood donors in the world.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We searched PubMed, EMBASE, Scopus and Google Scholar databases for records up to January 2019 and included studies reporting HPgV\u20101 virus prevalence amongst healthy volunteer blood donors based on the detection of HPgV\u20101 RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, we included 79 studies for the systematic review and 63 for the meta\u2010analysis. Based on the random effect meta\u2010analysis of 35\u00a0468 volunteer blood donors, we found the global prevalence of HPgV\u20101 to be 3\u00b71% (95% CI, 2\u00b74\u20134\u00b71). The pooled prevalences of HPgV\u20101 were 1\u00b77% (95% CI, 1\u00b71\u20132\u00b76) in North America, 9\u00b71% (95% CI, 6\u00b74\u201312\u00b77) in South America, 2\u00b73% (95% CI, 2%, 2\u00b78) in Europe and 2\u00b74% (95% CI, 1\u00b74\u20134) in Asia. Subgroup analyses based on age, gender or risk factors were not possible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Approximately 3 in 100 blood donations worldwide are positive for HPgV\u20101 increasing the risk of infection from transfusion of their components to subsequent recipients. Further research on virus pathogenicity is required before recommending routine screening of HPgV\u20101 for healthy volunteer blood donors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12876","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T08:00:31Z","timestamp":1576569631000},"page":"107-119","source":"Crossref","is-referenced-by-count":32,"title":["Global prevalence of human pegivirus\u20101 in healthy volunteer blood donors: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-5398","authenticated-orcid":false,"given":"Na","family":"Yang","sequence":"first","affiliation":[{"name":"Yantai Central Blood Station Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run","family":"Dai","sequence":"additional","affiliation":[{"name":"Yantai Central Blood Station Yantai 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