{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:00:56Z","timestamp":1791900056064,"version":"4.3.4"},"reference-count":84,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470351"],"award-info":[{"award-number":["81470351"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670173"],"award-info":[{"award-number":["81670173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Platelet has been linked to thrombosis in several studies. Inflammation is closely intertwined with thrombosis and occurs consecutively; it is therefore conceivable that platelet transfusions perform an increasingly vital role in inflammation. As platelet transfusions have been a significant therapeutic approach in patients for decades, serious risks including viral transmission, bacterial sepsis and acute lung injury have been demonstrated by retrospective studies and randomized clinical trials. Recent data suggest associations among platelet transfusion and pro\u2010inflammatory responses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A systematic review (from 2014\u00a0to 2019) on English literatures was conducted. Data on platelet transfusion\u2010related reactions were abstracted. Preset inclusion and exclusion criteria were applied to identify all eligible articles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients abstracted have received platelet transfusion. This new review focuses on recent 5\u2010year advances (from 2014 to 2019) to have found that the platelet transfusion as pro\u2010inflammatory process, concerning secretion of platelet microparticles and other inflammatory factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It can be hypothesized that the platelet microparticles or biological response modifier pathways might be innovative and therapeutic approaches to improving platelet transfusion and pretransfusion manipulations to reduce transfusion\u2010related adverse reactions and therefore improve the efficacy and safety of this wide\u2010employed therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12879","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T10:09:26Z","timestamp":1586945366000},"page":"349-357","source":"Crossref","is-referenced-by-count":30,"title":["Pro\u2010inflammatory effects after platelet transfusion: a review"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3512-1526","authenticated-orcid":false,"given":"Bin\u2010Zhen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Huashan Hospital Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1972.tb16342.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/tmrv.2003.50009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00304.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40673"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/978-1-4613-2577-2","volume-title":"Supportive Therapy in Haematology","author":"Das PC","year":"1985"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06981-9.50028-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14168"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61198-2"},{"key":"e_1_2_7_10_1","first-page":"809","article-title":"Platelet transfusion in hematology, oncology and surgery","volume":"111","author":"Wandt H","year":"2014","journal-title":"Dtsch Arztebl Int"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"e_1_2_7_12_1","unstructured":"H.A.S. A.N.S.M.:Recommandation de bonne pratique: transfusion de plaquettes: produits indications.2015:1\u201350"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.06.006"},{"key":"e_1_2_7_14_1","first-page":"447","article-title":"Perioperative platelet transfusion. Recommendations of the French Health Products Safety Agency (AFSSAPS) 2003","volume":"72","author":"Samama CM","year":"2006","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.11.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1589"},{"issue":"11","key":"e_1_2_7_17_1","first-page":"CD010983","article-title":"Comparison of different platelet count thresholds to guide administration of prophylactic platelet transfusion for preventing bleeding in people with haematological disorders after myelosuppressive chemotherapy or stem cell transplantation","author":"Estcourt LJ","year":"2015","journal-title":"Cochrane Db Syst Rev"},{"key":"e_1_2_7_18_1","first-page":"81","article-title":"Expert consensus on clinical pathway of blood component infusion","volume":"31","author":"(CSBT) CSoBT","year":"2018","journal-title":"J Clin Hematol (China)"},{"key":"e_1_2_7_19_1","first-page":"109","article-title":"Improving platelet transfusion safety: biomedical and technical considerations","volume":"14","author":"Garraud O","year":"2016","journal-title":"Blood Transfus\u2010Italy"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.030"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.06.004"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12622"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.124"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097082"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020387"},{"key":"e_1_2_7_26_1","first-page":"145","article-title":"Platelet\u2010, leucocyte\u2010 and red cell\u2010derived microparticles in stored whole blood, with and without leucofiltration, with and without ionising radiation","volume":"16","author":"Saito S","year":"2018","journal-title":"Blood Transfus\u2010Italy"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15111"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2016.1243789"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14973"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/35393"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-49040-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.03.006"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.11.006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00070"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.SCI-18.SCI-18"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.12.015"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12190"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.10.012"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615688"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2015.10.013"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03720.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01385.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20112322"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.110.110"},{"key":"e_1_2_7_45_1","first-page":"890","article-title":"Platelets release mitochondria serving as substrate for bactericidal group IIA\u2010secreted phospholipase A(2) to promote inflammation (vol 124, pg 2173, 2014)","volume":"125","author":"Boudreau LH","year":"2015","journal-title":"Blood"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13535"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15300"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-08-0632"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13475"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30392-0"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.7326\/ACPJC-2016-165-4-019"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30478-0"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-605493"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2014.01.001"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2014.05.003"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03539.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12146"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14890"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12088"},{"key":"e_1_2_7_60_1","first-page":"213a","article-title":"Estimated Financial Impact of Complying with the FDA Draft Guidance Entitled \"Bacterial Risk Control Strategies for Blood Collection Establishments and Transfusion Services to Enhance the Safety and Availability of Platelets for Transfusion\"","volume":"56","author":"Sorkin EJ","year":"2016","journal-title":"Transfusion"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2001.00280.x"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12811"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-860809"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12816"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002989"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-12-758185"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.04.37"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13021"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000081"},{"key":"e_1_2_7_70_1","first-page":"109","article-title":"Improving platelet transfusion safety: biomedical and technical considerations","volume":"14","author":"Garraud O","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12542"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000852"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08444.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2212-9"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00028"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01559.x"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03514.x"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2011.06.001"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.03.002"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-622233"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1586\/17474086.2016.1152177"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2017.1371289"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0895"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2015.00290"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.06.016"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvox.12879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.12879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:01:30Z","timestamp":1693890090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,15]]},"references-count":84,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1111\/vox.12879"],"URL":"https:\/\/doi.org\/10.1111\/vox.12879","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,15]]}}}