{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:05:45Z","timestamp":1783688745374,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,12]],"date-time":"2020-01-12T00:00:00Z","timestamp":1578787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Emerging viruses like severe acute respiratory syndrome coronavirus (SARS\u2010CoV), Crimean\u2013Congo haemorrhagic fever virus (CCHFV) and Nipah virus (NiV) have been identified to pose a potential threat to transfusion safety. In this study, the ability of the THERAFLEX UV\u2010Platelets and THERAFLEX MB\u2010Plasma pathogen inactivation systems to inactivate these viruses in platelet concentrates and plasma, respectively, was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Blood products were spiked with SARS\u2010CoV, CCHFV or NiV, and then treated with increasing doses of UVC light (THERAFLEX UV\u2010Platelets) or with methylene blue (MB) plus increasing doses of visible light (MB\/light; THERAFLEX MB\u2010Plasma). Samples were taken before and after treatment with each illumination dose and tested for residual infectivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treatment with half to three\u2010fourths of the full UVC dose (0\u00b72\u00a0J\/cm<jats:sup>2<\/jats:sup>) reduced the infectivity of SARS\u2010CoV (\u22653\u00b74 log), CCHFV (\u22652\u00b72 log) and NiV (\u22654\u00b73 log) to the limit of detection (LOD) in platelet concentrates, and treatment with MB and a fourth of the full light dose (120\u00a0J\/cm<jats:sup>2<\/jats:sup>) decreased that of SARS\u2010CoV (\u22653\u00b71 log), CCHFV (\u22653\u00b72 log) and NiV (\u22652\u00b77 log) to the LOD in plasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that both THERAFLEX UV\u2010Platelets (UVC) and THERAFLEX MB\u2010Plasma (MB\/light) effectively reduce the infectivity of SARS\u2010CoV, CCHFV and NiV in platelet concentrates and plasma, respectively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12888","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T06:24:05Z","timestamp":1578896645000},"page":"146-151","source":"Crossref","is-referenced-by-count":122,"title":["Inactivation of three emerging viruses \u2013 severe acute respiratory syndrome coronavirus, Crimean\u2013Congo haemorrhagic fever virus and Nipah virus \u2013 in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light"],"prefix":"10.1111","volume":"115","author":[{"given":"Markus","family":"Eickmann","sequence":"first","affiliation":[{"name":"Institute for Virology Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Gravemann","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Service NSTOB Springe 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