{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:03:00Z","timestamp":1761490980545,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donor haemoglobin concentration (Hb) is commonly measured from a skin\u2010prick sample. However, the skin\u2010prick sample is prone to preanalytical error and variation, which may lead to false deferrals due to low Hb.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Methods<\/jats:title><jats:p>We assessed the efficacy of two second\u2010line screening models for the evaluation of blood donors failing the initial skin\u2010prick test. In the venous model (<jats:italic>n<\/jats:italic>\u00a0=\u00a0305), Hb was measured from a venous sample at the donation site. In the skin\u2010prick model (<jats:italic>n<\/jats:italic>\u00a0=\u00a0331), two additional skin\u2010prick samples were measured. All on\u2010site Hb measurements were performed with HemoCue Hb201+ (HemoCue AB) point\u2010of\u2010care (POC) device. Hb in the venous samples was later also determined with a hematology analyzer (Sysmex XN, Sysmex Co.) to obtain the donor\u2019s correct Hb. A questionnaire evaluated Blood Service nurses\u2019 preferences regarding Hb assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significantly less donors were deferred from donation with venous model (40%) than with skin\u2010prick model (51%; chi\u2010square test <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004). Only two donors (0\u00b77%) were incorrectly accepted in the venous model. Further, Blood Service nurses preferred venous model over skin\u2010prick model. After the study, the venous model was implemented nationwide, and in the first two months after implementation, the deferral rate due to low Hb decreased from 2\u00b77% to 1\u00b79%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A venous sample for blood donor Hb second\u2010line screening significantly decreased low Hb deferrals compared to repeated skin\u2010prick testing without compromising donor safety. Valuable donations can be recovered by implementing a practical second\u2010line screening model based on venous sampling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12920","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T02:56:26Z","timestamp":1587437786000},"page":"617-623","source":"Crossref","is-referenced-by-count":6,"title":["Venous sample is superior to repeated skin\u2010prick testing in blood donor haemoglobin second\u2010line screening"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-5589","authenticated-orcid":false,"given":"Sari","family":"B\u00e4ckman","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Valkeaj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piia","family":"Korkalainen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-8488","authenticated-orcid":false,"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03353.x"},{"key":"e_1_2_7_3_1","first-page":"32","article-title":"Commission Directive 2004\/33\/EC Implementing Directive 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