{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:21:57Z","timestamp":1784168517357,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Use of convalescent plasma for coronavirus disease 2019 (COVID\u201019) treatment has gained interest worldwide. However, there is lack of evidence on its dosing, safety and effectiveness. Until data from clinical studies are available to provide solid evidence for worldwide applicable guidelines, there is a need to provide guidance to the transfusion community and researchers on this emergent therapeutic option. This paper aims to identify existing key gaps in current knowledge in the clinical application of COVID\u201019 convalescent plasma (CCP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The International Society of Blood Transfusion (ISBT) initiated a multidisciplinary working group with worldwide representation from all six continents with the aim of reviewing existing practices on CCP use from donor, product and patient perspectives. A subgroup of clinical transfusion professionals was formed to draft a document for CCP clinical application to identify the gaps in knowledge in existing literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Gaps in knowledge were identified in the following main domains: study design, patient eligibility, CCP dose, frequency and timing of CCP administration, parameters to assess response to CCP treatment and long\u2010term outcome, adverse events and CCP application in less\u2010resourced countries as well as in paediatrics and neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This paper outlines a framework of gaps in the knowledge of clinical deployment of CPP that were identified as being most relevant. Studies to address the identified gaps are required to provide better evidence on the effectiveness and safety of CCP use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12973","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T19:04:04Z","timestamp":1592247844000},"page":"88-98","source":"Crossref","is-referenced-by-count":31,"title":["Clinical use of Convalescent Plasma in the COVID\u201019 pandemic: a transfusion\u2010focussed gap analysis with recommendations for future research priorities"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-0650","authenticated-orcid":false,"given":"Arwa Z.","family":"Al\u2010Riyami","sequence":"first","affiliation":[{"name":"Department of Haematology Sultan Qaboos University Hospital Muscat Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine and Immunohaematology German Red Cross Blood Donor Service Baden\u2010W\u00fcrttemberg\u2010Hessen gGmbH Goethe University Hospital Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Medical Division Translational Research Department South African National Blood Service Port Elizabeth South Africa"},{"name":"Division Clinical Haematology Department of Medicine University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9517","authenticated-orcid":false,"given":"Evan M.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise J.","family":"Estcourt","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine University of Oxford and NHS Blood and Transplant Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins Hospital Baltimore MD USA"},{"name":"Division of Hematology\/Oncology Simmons Cancer Institute at SIU School of Medicine and Mississippi Valley Regional Blood Center Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-5434","authenticated-orcid":false,"given":"Salwa","family":"Hindawi","sequence":"additional","affiliation":[{"name":"Haematology Department Faculty of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra D.","family":"Josephson","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Center for Transfusion and Cellular Therapies Emory University School of Medicine Atlanta GE USA"},{"name":"Department of Pediatrics Aflac Cancer Center and Blood Disorders Children's Healthcare of Atlanta Emory University School of Medicine Atlanta GE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Land","sequence":"additional","affiliation":[{"name":"Corporate Medical Affairs Vitalant Phoenix AZ USA"},{"name":"Department of Pathology UT Health Science San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe K.","family":"McQuilten","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University Melbourne VIC Australia"},{"name":"Department of Clinical Haematology Monash Health Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Spitalnik","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Cell Biology Columbia University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Transfusion Research Unit School of Public Health and Preventive Medicine Monash University Melbourne VIC Australia"},{"name":"Department of Clinical Haematology Monash Health Melbourne VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana V.","family":"Devine","sequence":"additional","affiliation":[{"name":"Canadian Blood Services Vancouver BC Canada"},{"name":"Department of Pathology &amp; Laboratory Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-2865","authenticated-orcid":false,"given":"Cynthia","family":"So\u2010Osman","sequence":"additional","affiliation":[{"name":"Department Unit Transfusion Medicine Sanquin Blood Supply Foundation Amsterdam The Netherlands"},{"name":"Department Haematology Erasmus Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,3]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization:Coronavirus disease (COVID\u201019) outbreak.https:\/\/www.who.int\/westernpacific\/emergencies\/covid\u201019. 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