{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:44:03Z","timestamp":1776948243043,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Delayed syncopal\u2010type complications are infrequent among blood donors, but sometimes have critical consequences, such as severe injury. We retrospectively investigated the characteristics of donors with delayed syncopal\u2010type complications or falls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design and methods<\/jats:title><jats:p>We defined a delayed reaction (DR) as syncopal\u2010type complications occurring &gt;20\u00a0min after needle removal. Subjects were stratified by sex, age, estimated blood volume (EBV), body mass index (BMI) and frequency of donation. Multiple logistic regression analysis and propensity score weighted M estimation were performed to evaluate the covariate\u2010adjusted risk of syncopal DRs among donors giving 400\u00a0ml of whole blood (WB). The DR rate was calculated as the number of DRs divided by the number of all syncopal\u2010type reactions after needle removal. The risk of falls was assessed similarly. Donors who discontinued before completing phlebotomy (donation of 400\u00a0ml) were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 3818 syncopal\u2010type reactions after needle removal, there were 359 DRs and 93 falls. Elderly donors and female donors with syncopal\u2010type reactions had a significantly higher risk of DRs (<jats:italic>P<\/jats:italic> for trend\u00a0&lt;\u00a00\u00b7001). Elderly donors with syncopal\u2010type reactions also had a higher risk of falls (<jats:italic>P<\/jats:italic> for trend\u00a0&lt;\u00a00\u00b7001). Among all donors with syncopal\u2010type reactions, the risk of DRs or falls was not correlated with EBV, BMI or donation frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In female donors and elderly donors (donating 400\u00a0ml of WB), syncopal\u2010type reactions tended to be delayed. Elderly donors with syncopal\u2010type reactions had a significantly higher risk of falls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12981","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T20:19:20Z","timestamp":1595535560000},"page":"36-41","source":"Crossref","is-referenced-by-count":3,"title":["Syncopal\u2010type reactions tend to be delayed and result in falls among elderly blood donors"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2951-3451","authenticated-orcid":false,"given":"Noriko","family":"Namba","sequence":"first","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7668-6083","authenticated-orcid":false,"given":"Fumihiko","family":"Ishimaru","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaku","family":"Kondo","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuma","family":"Hashizume","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kunii","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Shibata","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Kato","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Tokyo Metropolitan Blood Center Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01811.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2012.07.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39399219291.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2009.02397.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12418"},{"key":"e_1_2_7_7_1","unstructured":"Blood Services 2019.Japanese Red Cross 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