{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:04:03Z","timestamp":1778630643320,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,8]],"date-time":"2020-09-08T00:00:00Z","timestamp":1599523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Haemorrhagic shock is a leading cause of avoidable mortality in prehospital care. For several years, our centre has followed a procedure of transfusing two units of packed red blood cells outside the hospital. Our study\u2019s aim was twofold: describe the patient characteristics of those receiving prehospital blood transfusions and analyse risk factors for the 7\u2010day mortality rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed a monocentric retrospective observational study. Demographic and physiological data were recovered from medical records. The primary outcome was mortality at seven days for all causes. All patients receiving prehospital blood transfusions between 2013 and 2018 were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 116 eligible patients, 56 patients received transfusions. Trauma patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a018) were younger than medical patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012), had lower systolic blood pressure (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and had higher haemoglobin levels (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7016). Mortality was higher in the trauma group than the medical group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7015). In\u2010hospital trauma patients received more fresh\u2010frozen plasma and platelet concentrate than medical patients (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Predictive factors of 7\u2010day mortality included transfusion for trauma\u2010related reasons, low Glasgow Coma Scale, low peripheral oxygen saturation, prehospital intensive resuscitation, existing coagulation disorders, acidosis and hyperlactataemia (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current guidelines recommend early transfusion in patients with haemorrhagic shock. Prehospital blood transfusions are safe. Coagulation disorders and acidosis remain a cause of premature death in patients with prehospital transfusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12984","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T03:52:20Z","timestamp":1607485940000},"page":"745-755","source":"Crossref","is-referenced-by-count":8,"title":["Civilian prehospital transfusion \u2013 experiences from a French region"],"prefix":"10.1111","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-0076","authenticated-orcid":false,"given":"Arnaud","family":"Cassignol","sequence":"first","affiliation":[{"name":"SMUR Department Timone Hospital Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Marmin","sequence":"additional","affiliation":[{"name":"SMUR Department Timone Hospital Aix\u2010Marseille University  Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Mattei","sequence":"additional","affiliation":[{"name":"SMUR Department Sainte\u2010Musse Public Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9a","family":"Goffinet","sequence":"additional","affiliation":[{"name":"French Blood Establishment Sainte\u2010Musse Public Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Pons","sequence":"additional","affiliation":[{"name":"French Blood Establishment Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lien","family":"Renard","sequence":"additional","affiliation":[{"name":"Emergency Department Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Demory","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Sainte\u2010Musse Public Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Bordes","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.10.037"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0266-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9087-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e31827ce168"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-077370"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/131.12.1469"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-1383(93)90023-Y"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199901000-00030"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000000633"},{"key":"e_1_2_8_11_1","first-page":"373","article-title":"Feasibility of prehospital freeze\u2010dried plasma administration in a UK Helicopter Emergency Medical Service. 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