{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:33:57Z","timestamp":1773830037085,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload (TACO) is the leading cause of transfusion\u2010related morbidity and mortality. A recently completed pilot trial randomized patients to pre\u2010transfusion furosemide versus placebo but had a slower than expected enrollment rate. We sought to determine whether the lack of recruitment was due to a paucity of eligible patients or excessively restrictive eligibility criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>At 10 sites, eligible patients were retrospectively identified by first screening blood bank databases over one month for all transfusion episodes meeting trial inclusion criteria, defined as non\u2010surgical patients receiving single RBC unit transfusions. The age threshold was decreased from 65 to 50\u00a0years. The first 10 patients meeting inclusion criteria then underwent detailed chart review for the exclusion criteria. The incidence of TACO and furosemide use was also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 10 sites, 11\u00a0969 red cell units were transfused over 1\u00a0month and 1356 met the inclusion criteria. Of the 100 charts reviewed, 60 (60%) had no exclusion criteria. Active bleeding was the most common reason for ineligibility. There were 813 eligible transfusion episodes. Of the eligible patients, 17 (28\u00b73%) had evidence of congestive heart failure, and furosemide was prescribed in 24 (40%). Despite the use of a lower age threshold, three cases of TACO were detected with an incidence of 3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A large number of transfusion episodes met eligibility criteria. With a 3% incidence of TACO, 50% decrease through the use pre\u2010transfusion furosemide and a target consent rate of 30%, a definitive trial of approximately 3000 patients could be completed within 1\u00a0year.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.12994","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T14:33:42Z","timestamp":1603722822000},"page":"434-439","source":"Crossref","is-referenced-by-count":7,"title":["TACO\u2010BEL\u20103: a feasibility study and a retrospective audit of diuretics for patients receiving blood transfusion at ten hospitals"],"prefix":"10.1111","volume":"116","author":[{"given":"Aditi","family":"Khandelwal","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Canadian Blood Services Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-9020","authenticated-orcid":false,"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-6406","authenticated-orcid":false,"given":"Christine","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muntadhar","family":"Al Moosawi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Armali","sequence":"additional","affiliation":[{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"},{"name":"Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Arnold","sequence":"additional","affiliation":[{"name":"Hamilton General Hospital Hamilton ON Canada"},{"name":"Juravinski Cancer Centre Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Dallas","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada"},{"name":"St. Paul Hospital Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lani","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Pavenski","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"},{"name":"St Michael\u2019s Hospital Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Rioux\u2010Mass\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al Montreal PQ Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Shehata","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Canadian Blood Services Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"},{"name":"Mount Sinai Hospital Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada"},{"name":"Vancouver General Hospital Vancouver BC Canada"},{"name":"Centre for Blood Research University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Pendergrast","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON Canada"},{"name":"Laboratory Medicine Program University Health Network Toronto ON Canada"},{"name":"Education and Safety in Transfusion (QUEST) Research Program University of Toronto Quality in Utilization Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Public Health Agency of Canada:Health Canada Transfusion Transmitted Injuries Surveillance System 2006\u20132012 Report. 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[monograph on the internet].2015; Available from:http:\/\/www.aabb.org\/programs\/publications\/bulletins\/Docs\/ab15\u201002.pdf[Last accessed March 6 2020]"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15270"},{"key":"e_1_2_6_18_1","unstructured":"PopovskyM RobillardP SchipperusM et al.Proposed standard definitions for surveillance of non infectious adverse transfusion reactions.International Society of Blood Transfusion 2011.http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/Proposed_definitions_2011_surveillance_non_infectious_adverse_reactions_haemovigilance_incl_TRALI_correction_2013.pdf[Last accessed February 7 2020]"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199018050-00004"},{"issue":"2","key":"e_1_2_6_20_1","first-page":"CD010138","article-title":"Loop diuretics for patients receiving blood transfusions","author":"Sarai M","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12466"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.12994","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.12994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T03:21:08Z","timestamp":1693624868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.12994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/vox.12994"],"URL":"https:\/\/doi.org\/10.1111\/vox.12994","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,26]]}}}