{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:19:44Z","timestamp":1784636384306,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Incidence in first\u2010time and repeat blood donors is an important measure of transfusion\u2010transmitted HIV infection (TT\u2010HIV) risk. This study assessed HIV incidence over time at four large blood centres in Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Donations were screened and confirmed using serological assays for HIV from 2007 to 2016, and additionally screened by nucleic acid testing from 2011 forward. Limiting antigen (LAg) avidity testing was conducted on HIV seroreactive samples from first\u2010time donors to classify whether an infection was recently acquired. We calculated incidence in first\u2010time donors using the mean duration of recent infection and in repeat donors using classical methods. Time and demographic trends were assessed using Poisson regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over the 10\u2010year period, HIV incidence in first\u2010time donors was highest in Recife (45\u00b71\/100\u00a0000 person\u2013years (10<jats:sup>5<\/jats:sup> py)) followed by S\u00e3o Paulo (32\u00b72\/10<jats:sup>5<\/jats:sup> py) and then Belo Horizonte (23\u00b73\/10<jats:sup>5<\/jats:sup> py), and in repeat donors was highest in Recife (33\u00b72\/10<jats:sup>5<\/jats:sup> py), Belo Horizonte (27\u00b75\/10<jats:sup>5<\/jats:sup> py) and S\u00e3o Paulo (17\u00b70\/10<jats:sup>5<\/jats:sup> py). Results from Rio de Janeiro were available from 2013 to 2016 with incidence in first\u2010time donors of 35\u00b79\/10<jats:sup>5<\/jats:sup> py and repeat donors from 2011 to 2016 of 29\u00b72\/10<jats:sup>5<\/jats:sup> py. Incidence varied by other donor demographics. When incidence was considered in 2\u2010year intervals, no significant trend was evident. Overall residual risk of TT\u2010HIV was 5\u00b746 and 7\u00b741 per million units of pRBC and FFP transfused, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HIV incidence in both first\u2010time and repeat donors varied by region in Brazil. Clear secular trends were not evident.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13002","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T12:30:47Z","timestamp":1601469047000},"page":"207-216","source":"Crossref","is-referenced-by-count":14,"title":["10\u2010year analysis of human immunodeficiency virus incidence in first\u2010time and repeat donors in Brazil"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-2724","authenticated-orcid":false,"given":"Sheila","family":"de Oliveira Garcia Mateos","sequence":"first","affiliation":[{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Hemotherapy Hemorio Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Preiss","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Epidemiology RTI International Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thelma T.","family":"Gon\u00e7alez","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Di Lorenzo Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Sao Joao del\u2010Rei Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Grebe","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"},{"name":"University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Di Germanio","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mars","family":"Stone","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Amorim Filho","sequence":"additional","affiliation":[{"name":"Department of Hemotherapy Hemorio Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna B\u00e1rbara","family":"Carneiro Proietti","sequence":"additional","affiliation":[{"name":"Department GDTC (Technical\u2010Scientific Development Management) Hemominas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0166-4258","authenticated-orcid":false,"given":"Andre Rolim","family":"Belisario","sequence":"additional","affiliation":[{"name":"Department GDTC (Technical\u2010Scientific Development Management) Hemominas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-4634","authenticated-orcid":false,"given":"Cesar","family":"de Almeida\u2010Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Disciplina de Ci\u00eancias M\u00e9dicas Faculdade de Medicina Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Mendrone\u2010Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Loureiro","sequence":"additional","affiliation":[{"name":"Pernambuco University Recife Brazil"},{"name":"Funda\u00e7\u00e3o Hemope\/Hemocentro de Pernambuco Recife Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"},{"name":"University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Vitalant Research Institute San Francisco CA USA"},{"name":"University of California San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Cerdeira Sabino","sequence":"additional","affiliation":[{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Recipient Epidemiology, Donor Evaluation Study (REDS\u2010III) International Component Brazil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Blood safety and availability","author":"WHO","year":"2019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13939"},{"key":"e_1_2_9_4_1","first-page":"1","volume-title":"Sedia\u2122 HIV\u20101 LAg\u2010Avidity EIA: single well avidity enzyme immunoassay for detection of recent HIV\u20101 infection","author":"Corporation SB","year":"2018"},{"key":"e_1_2_9_5_1","unstructured":"ANVISA:Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. ANVISA PRODU\u00c7\u00c3O HEMOTER\u00c1PICA Hemoprod 2017.2018."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2011.0143"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03344.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14478"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114947"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200309050-00005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02804.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02423-08"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12299"},{"key":"e_1_2_9_14_1","unstructured":"GrebeE:Residual risk of HIV transfusion transmission with NAT screening. Zenodo 2019; Version v1.0"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14959"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2018.11.002"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2012.01643.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1036-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03358.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365646"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1246-7820(96)80007-3"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14146"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12204"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.10.02.00519-en"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.03.010"},{"key":"e_1_2_9_26_1","first-page":"422","article-title":"Prevalence, incidence and residual risk of transfusion\u2010transmitted hepatitis C virus and human immunodeficiency virus after the implementation of nucleic acid testing in Italy: a 7\u2010year (2009\u20132015) survey","volume":"16","author":"Velati C","year":"2018","journal-title":"Blood Transfus"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T09:13:17Z","timestamp":1693645997000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1111\/vox.13002"],"URL":"https:\/\/doi.org\/10.1111\/vox.13002","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}