{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:02:24Z","timestamp":1787162544976,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T00:00:00Z","timestamp":1607126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>The International Haemovigilance Network collects aggregate data on complications of blood donation from member haemovigilance systems (HVS). We analysed the data collected in 2006\u20132016 in order to learn from it and consider future improvements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>National HVS entered annual data on donation complications and on annual whole blood and apheresis donations in the \u2018ISTARE\u2019 (International Surveillance of Transfusion Adverse Reactions and Events) online database. We calculated national and aggregate donation complication rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010four HVS provided data for 138 country years (CY; median 7 CY, IQR 2\u20138), covering 155 M donations. The overall complication rate was 6\u00b73\/1000 donations and the median country rate 3\u00b72\/1000 (IQR 1\u00b71\u201310\u00b71). Overall and severe complication rates varied considerably between HVS. Vasovagal reactions (VVR) were most commonly reported: 4\u00b76\/1000 donations, median country rate 3\u00b71\/1000 donations (IQR 0\u00b76\u20137\u00b77). Rare complications included generalized allergic reaction (0\u00b710\/100\u00a0000) and major blood vessel injury (category available since 2015; 0\u00b712\/100\u00a0000). Eighteen HVS reported complications of whole blood donation (WBD) and apheresis separately (89 CY, 101\u00b76 M WBD and 26\u00b73 M apheresis donations). The median country VVR rate was 3\u00b74\/1000 WBD (IQR 1\u00b70\u20139\u00b71) and 1\u00b75\/1000 apheresis donations (1\u00b70\u20134\u00b72). Rates of venepuncture\u2010related complications tended to be higher for apheresis: the median country rate of reported haematomas was 0\u00b739\/1000 WBD (IQR 0\u00b731\u20131\u00b72) vs. 4\u00b72\/1000 apheresis donations (0\u00b769\u20135\u00b76).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>International reporting allows HVS to study rates of blood donation complications and capture information about very rare events. The present variability of reporting and severity assessment hampers comparisons between HVS and requires further work.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/vox.13048","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T08:31:01Z","timestamp":1607157061000},"page":"628-636","source":"Crossref","is-referenced-by-count":21,"title":["Complications of blood donation reported to haemovigilance systems: analysis of eleven years of international surveillance"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3451-9911","authenticated-orcid":false,"given":"Johanna C","family":"Wiersum\u2010Osselton","sequence":"first","affiliation":[{"name":"TRIP National Hemovigilance and Biovigilance Office  Leiden The Netherlands"},{"name":"Sanquin  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0272-7794","authenticated-orcid":false,"given":"Constantina","family":"Politis","sequence":"additional","affiliation":[{"name":"Coordinating Centre for Haemovigilance and Surveillance of Transfusion (SKAEM) Hellenic National Public Health Organisation  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Richardson","sequence":"additional","affiliation":[{"name":"Panteion University of Social and Political Sciences  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Goto","sequence":"additional","affiliation":[{"name":"Safety Vigilance Division Technical Department Blood Service Headquarters Japanese Red Cross Society  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisavet","family":"Grouzi","sequence":"additional","affiliation":[{"name":"Transfusion Service and Clinical Hemostasis of Saint Savvas Oncology Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marano","sequence":"additional","affiliation":[{"name":"Italian National Blood Centre  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J","family":"Land","sequence":"additional","affiliation":[{"name":"Vitalant  Phoenix AZ USA"},{"name":"Department of Pathology UT Health San Antonio San Antonio TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,5]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"S28","article-title":"Risk factors for complications in donors at first and repeat whole blood donation: a cohort study with assessment of the impact on donor return","volume":"12","author":"Wiersum\u2010Osselton JC","year":"2014","journal-title":"Blood Transfus."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2006.00905.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13034"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12447"},{"key":"e_1_2_11_6_1","unstructured":"Standard for Surveillance of Complications Related to Blood Donation.ISBT working party on haemovigilance in collaboration with the International Haemovigilance Network and the AABB Donor Haemovigilance Working Group. Available at. Available at:http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/Donor_Standard_Definitions_Final_2014.pdf[Last Accessed 1\u20105\u20102020]"},{"key":"e_1_2_11_7_1","unstructured":"Rationale for changes from 2008 to 2014 classification of adverse donor events.http:\/\/www.isbtweb.org\/fileadmin\/user_upload\/files-2015\/haemovigilance\/definitions\/Rationale%20changes%202008%20to%202014%20classification%20of%20complications%20of%20donation%20haemovigilance%202014.pdf[Last Accessed 1\u20105\u20102020]"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12323"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14948"},{"key":"e_1_2_11_10_1","volume-title":"Guide to the Preparation, Use and Quality Assurance of Blood Components","author":"Council of Europe"},{"key":"e_1_2_11_11_1","unstructured":"European Commission DG for Health and Food Safety:Summary of the 2018 annual reporting of serious adverse reactions and events for blood and blood components 2020. Ref. Ares (2020) 147152\u201310\/01\/2020https:\/\/ec.europa.eu\/health\/sites\/health\/files\/blood_tissues_organs\/docs\/2018_sare_blood_summary_en.pdf[Last Accessed 1\u20105\u20102020]"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15830"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15136"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01345.x"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13048","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T11:56:24Z","timestamp":1692618984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,5]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/vox.13048"],"URL":"https:\/\/doi.org\/10.1111\/vox.13048","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,5]]}}}