{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:38:27Z","timestamp":1790509107594,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015283","name":"Bloomberg Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["1K23HL151826\u201001"],"award-info":[{"award-number":["1K23HL151826\u201001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL059842"],"award-info":[{"award-number":["R01HL059842"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI052733"],"award-info":[{"award-number":["AI052733"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI15207"],"award-info":[{"award-number":["AI15207"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI120938"],"award-info":[{"award-number":["R01AI120938"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI120938S1"],"award-info":[{"award-number":["R01AI120938S1"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI128779"],"award-info":[{"award-number":["R01AI128779"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32AI102623"],"award-info":[{"award-number":["T32AI102623"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W911QY2090012"],"award-info":[{"award-number":["W911QY2090012"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>ABO blood group may affect risk of SARS\u2010CoV\u20102 infection and\/or severity of COVID\u201019. We sought to determine whether IgG, IgA and neutralizing antibody (nAb) to SARS\u2010CoV\u20102 vary by ABO blood group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Among eligible convalescent plasma donors, ABO blood group was determined via agglutination of reagent A1 and B cells, IgA and IgG were quantified using the Euroimmun anti\u2010SARS\u2010CoV\u20102 ELISA, and nAb titres were quantified using a microneutralization assay. Differences in titre distribution were examined by ABO blood group using non\u2010parametric Kruskal\u2013Wallis tests. Adjusted prevalence ratios (aPR) of high nAb titre (\u22651:160) were estimated by blood group using multivariable modified Poisson regression models that adjusted for age, sex, hospitalization status and time since SARS\u2010CoV\u20102 diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 202 potential donors, 65 (32%) were blood group A, 39 (19%) were group B, 13 (6%) were group AB, and 85 (42%) were group O. Distribution of nAb titres significantly differed by ABO blood group, whereas there were no significant differences in anti\u2010spike IgA or anti\u2010spike IgG titres by ABO blood group. There were significantly more individuals with high nAb titre (\u22651:160) among those with blood group B, compared with group O (aPR\u00a0=\u00a01\u00b79 [95%CI\u00a0=\u00a01\u00b71\u20133\u00b73], <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7029). Fewer individuals had a high nAb titre among those with blood group A, compared with group B (aPR\u00a0=\u00a00\u00b76 [95%CI\u00a0=\u00a00\u00b74\u20101\u00b70], <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7053).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Eligible CCP donors with blood group B may have relatively higher neutralizing antibody titres. Additional studies evaluating ABO blood groups and antibody titres that incorporate COVID\u201019 severity are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13070","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T22:45:25Z","timestamp":1611614725000},"page":"766-773","source":"Crossref","is-referenced-by-count":23,"title":["ABO blood group and SARS\u2010CoV\u20102 antibody response in a convalescent donor population"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8181-9517","authenticated-orcid":false,"given":"Evan M.","family":"Bloch","sequence":"first","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eshan U.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"},{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi","family":"Marshall","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Littlefield","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"},{"name":"Mississippi Valley Regional Blood Center Springfield IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1500-8211","authenticated-orcid":false,"given":"Brenda J.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Pathology and Immunology Washington University School of Medicine in St. Louis St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Winters","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchee","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imani","family":"Burgess","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Laeyendecker","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Allergy and Infectious Diseases National Institutes of Health Baltimore MD USA"},{"name":"Department of Infectious Diseases Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shmuel","family":"Shoham","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-3899","authenticated-orcid":false,"given":"Eric A.","family":"Gehrie","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Redd","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Allergy and Infectious Diseases National Institutes of Health Baltimore MD USA"},{"name":"Department of Infectious Diseases Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Division of Intramural Research National Institute of Allergy and Infectious Diseases National Institutes of Health Baltimore MD USA"},{"name":"Department of Infectious Diseases Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Casadevall","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Pekosz","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology and Immunology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron A. R.","family":"Tobian","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Department of Pathology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"JHU:Coronavirus COVID\u201019 Global Cases by the Center for Systems Science and Engineering at Johns Hopkins. The Center for Systems Science and Engineering (CSSE) at JHU December 5 2020 2020.https:\/\/coronavirus.jhu.edu\/map.html(Last accessed December 5 2020)"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.06.026"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00404"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16811"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1150"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16984"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04169-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15946"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104880"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-14"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.12.1450-c"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwn093"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16932"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16884"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138745"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15910"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.09.16.20196154"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007714"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102957"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007638"},{"key":"e_1_2_8_22_1","volume-title":"Technical Manual","author":"Cohn C","year":"2020"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142004"},{"key":"e_1_2_8_24_1","unstructured":"FDA:Recommendations for investigational COVID\u201019 convalescent plasma.2020.https:\/\/www.fda.gov\/vaccines\u2010blood\u2010biologics\/investigational\u2010new\u2010drug\u2010ind\u2010or\u2010device\u2010exemption\u2010ide\u2010process\u2010cber\/recommendations\u2010investigational\u2010covid\u201019\u2010convalescent\u2010plasma(Last accessed May 18 2020)"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa581"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-2005-395"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0239508"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2020283"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200841"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0913-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02257\u201020"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02020\u201020"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02005\u201020"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0897-1"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1389"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa574"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15415"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13070","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13070","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111\/vox.13070","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13070","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T02:24:45Z","timestamp":1693103085000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/vox.13070"],"URL":"https:\/\/doi.org\/10.1111\/vox.13070","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]}}}