{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:24:57Z","timestamp":1790141097272,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Citrate\u2010based anticoagulation reduces plasma potassium and free magnesium in patients undergoing peripheral stem cell collections. Whether the effects may be mitigated by pre\u2010procedure oral electrolyte supplements has not been previously assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Results from a historic cohort (2010\u20132013) guided a systematic prospective intervention in subjects deemed at risk for clinically meaningful hypokalaemia and hypomagnesaemia. From 2015 to 2019, 136 patients were enrolled in the study. Pre\u2010 and post\u2010apheresis electrolyte levels were measured, and oral potassium and magnesium supplements were systematically administered based on the pre\u2010 electrolyte levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We saw a 37% absolute reduction in severe hypokalaemia and 39% absolute reduction in hypomagnesaemia in the prospective intervention cohort when compared to the historic cohort. Multivariate analyses indicated that part of the effect was due to the electrolyte intervention, while part of the effect likely stemmed from other procedure\u2010related changes implemented during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral potassium and magnesium prophylaxis appear to reduce hypokalaemia and hypomagnesaemia following peripheral stem cell collection. Whether the effect size is sufficient to motivate the intervention warrants further investigation, preferably in a prospective randomized trial setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13075","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T18:54:19Z","timestamp":1611600859000},"page":"916-923","source":"Crossref","is-referenced-by-count":4,"title":["Prevention of hypokalaemia and hypomagnesaemia following peripheral stem cell collection \u2013 a prospective cohort study"],"prefix":"10.1111","volume":"116","author":[{"given":"Lars","family":"Skagerlind","sequence":"first","affiliation":[{"name":"Department of Haematology Ume\u00e5 University Hospital Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-3250","authenticated-orcid":false,"given":"Fredrik","family":"Toss","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Division of Clinical Immunology Ume\u00e5 University Ume\u00e5 Sweden"},{"name":"Department of Integrative Medical Biology Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-020-0826-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2016.01.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13668"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-1101(2000)15:4<230::AID-JCA3>3.0.CO;2-B"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2001.41091165.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2003.00513.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1878"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00151.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1997.37497265343.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2013.06.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21713"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2005.00576.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)10535-9"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011040414"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.21222"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)85044-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2005.11.002"},{"key":"e_1_2_10_19_1","first-page":"233","article-title":"Electrolyte disorders and arrhythmogenesis","volume":"18","author":"El\u2010Sherif N","year":"2011","journal-title":"Cardiol J"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.71.4.645"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(86)90674-5"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-200207000-00006"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00144.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(93)90036-C"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun193"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.109"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13075","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13075","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T21:26:13Z","timestamp":1693344373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,25]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/vox.13075"],"URL":"https:\/\/doi.org\/10.1111\/vox.13075","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,25]]}}}