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The level of evidence supporting an association between ABO type and SARS\u2010CoV\u20102\/COVID\u201019 ranges from small observational studies, to genome\u2010wide\u2010association\u2010analyses and country\u2010level meta\u2010regression analyses. ABO blood group antigens are oligosaccharides expressed on red cells and other tissues (notably endothelium). There are several hypotheses to explain the differences in SARS\u2010CoV\u20102 infection by ABO type. For example, anti\u2010A and\/or anti\u2010B antibodies (e.g. present in group O individuals) could bind to corresponding antigens on the viral envelope and contribute to viral neutralization, thereby preventing target cell infection. The SARS\u2010CoV\u20102 virus and SARS\u2010CoV spike (S) proteins may be bound by anti\u2010A isoagglutinins (e.g. present in group O and group B individuals), which may block interactions between virus and angiotensin\u2010converting\u2010enzyme\u20102\u2010receptor, thereby preventing entry into lung epithelial cells. ABO type\u2010associated variations in angiotensin\u2010converting enzyme\u20101 activity and levels of von Willebrand factor (VWF) and factor VIII could also influence adverse outcomes, notably in group A individuals who express high VWF levels. In conclusion, group O may be associated with a lower risk of SARS\u2010CoV\u20102 infection and group A may be associated with a higher risk of SARS\u2010CoV\u20102 infection along with severe disease. However, prospective and mechanistic studies are needed to verify several of the proposed associations. Based on the strength of available studies, there are insufficient data for guiding policy in this regard.<\/jats:p>","DOI":"10.1111\/vox.13076","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T15:23:43Z","timestamp":1613316223000},"page":"849-861","source":"Crossref","is-referenced-by-count":126,"title":["ABO blood group and COVID\u201019: a review on behalf of the ISBT COVID\u201019 Working Group"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-9905","authenticated-orcid":false,"given":"Ruchika","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Pathology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Division of Hematology\/Oncology Simmons Cancer Institute at SIU School of Medicine and Mississippi Valley Regional Blood Center Springfield IL 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