{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:33:47Z","timestamp":1784950427101,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>It is proposed that severe leucocytosis mainly contributes to pulmonary hypertension by blocking pulmonary capillaries and restricting blood flow. Exchange transfusion (ET) in pertussis has been demonstrated as a safe and useful technique for depleting the leucocyte mass. We aim to discuss four cases of pertussis\u2010induced respiratory distress and the effectiveness of ET in such a setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We conducted a retrospective case series at the Infectious Disease Department of Children\u2019s Hospital 2 in Ho Chi Minh City, Vietnam, and included four pertussis patients that were confirmed by PCR tests on respiratory secretions, presented with severe leucocytosis and respiratory distress and required mechanical ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the included patients, three underwent a double volume ET for leucodepletion, two of whom were discharged after the procedure with proper vitals and laboratory test results. On the other hand, one patient died despite ET, performed late in the course of the disease. Exchange transfusion was not performed in the last patient who died as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early ET may be a useful and rapid life\u2010saving treatment in children with critical pertussis and severe leucocytosis before cardiopulmonary complications appear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13085","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T15:29:38Z","timestamp":1621351778000},"page":"976-982","source":"Crossref","is-referenced-by-count":13,"title":["Exchange transfusion in the management of critical pertussis in young infants: a case series"],"prefix":"10.1111","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-1384","authenticated-orcid":false,"given":"Pham Thai","family":"Son","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital No.2 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2180-0029","authenticated-orcid":false,"given":"Abdullah","family":"Reda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Al \u2013 Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Chau","family":"Viet","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital No.2 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Xuan Thuy","family":"Quynh","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital No.2 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dang The","family":"Hung","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Ho Chi Minh City Viet Nam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tring Huu","family":"Tung","sequence":"additional","affiliation":[{"name":"Children's Hospital No.2 Ho Chi Minh Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9543-9440","authenticated-orcid":false,"given":"Nguyen Tien","family":"Huy","sequence":"additional","affiliation":[{"name":"School of Tropical Medicine and Global Health Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2016.02.032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00083-15"},{"key":"e_1_2_8_4_1","unstructured":"WHO:Immunization Vaccines and Biologicals: Pertussis. 25 July 2019 2019.https:\/\/www.who.int\/immunization\/monitoring_surveillance\/burden\/vpd\/surveillance_type\/passive\/pertussis\/en\/(Last accessed 2019)."},{"key":"e_1_2_8_5_1","unstructured":"WHO:Incidence time series for Viet Nam. 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