{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T17:35:46Z","timestamp":1781285746913,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/objectives<\/jats:title><jats:p>Transfusion reactions (TRs) may cause or contribute to death. Cardiopulmonary TRs are distressing, and collectively account for most transfusion fatalities, though the degree to which they alter survival more broadly is unclear. Deaths (and their timing) after TRs may provide further insights.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>Adult (tri\u2010hospital network) haemovigilance data (2013\u20132016) recorded referrals with conclusions ranging from unrelated to transfusion (UTR) to entities such as: septic TRs, serologic\/haemolytic reactions, transfusion\u2010associated circulatory overload (TACO), transfusion\u2010associated dyspnoea (TAD), transfusion\u2010related acute lung injury (TRALI), allergic transfusion reaction (ATR), and others. For (in\u2010 or out\u2010patient) visits involving suspected TRs (VISTRs), all\u2010cause mortalities (% [95% confidence interval]) and associated time\u2010to\u2010death (TTD) (median days, [interquartile range]) were compared. Diagnoses were defined inclusively (possible\u2010to\u2010definite) or strictly (probable\u2010to\u2010definite).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1144 events, rank order VISTR mortality following (possible\u2010to\u2010definite) TRs, and associated TTDs, were led by: DHTR 33% [6\u201319], 1 death at 123d; TRALI 32% [15\u201354], 6 deaths: 3d [2\u201320]; BaCon 21% [14\u201331], 17 deaths: 10d [3\u201328]; TACO 18% [12\u201326], 23 deaths: 16d [6\u201328]; TAD 17% [11\u201326]: 18 deaths, 6d [3\u201312]. Higher\u2010certainty TRs ranked similarly (DHTR 50% [9\u201391]; BaCon 29% [12\u201355], 4 deaths: 12d [3\u201322]; and TACO 25% [16\u201338], 15 deaths: 21d [6\u201328]). VISTR mortality after TACO or TRALI significantly exceeded ATR (3\u00b73% [2\u00b74\u20135\u00b78], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b700001) but was not different from UTR events (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b73).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only half of cardiopulmonary TRs constituted high certainty diagnoses. Nevertheless, cardiopulmonary TRs and suspected BaCon marked higher VISTR mortality with shorter TTDs. Short (&lt;1\u00a0week) TTDs in TAD, BaCon or TRALI imply either contributing roles in death, treatment refractoriness and\/or applicable TR susceptibilities in the dying.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13086","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T12:44:01Z","timestamp":1614343441000},"page":"898-909","source":"Crossref","is-referenced-by-count":5,"title":["Frequency and timing of all\u2010cause deaths in visits involving suspected transfusion reactions, and the significance of cardiopulmonary disturbances"],"prefix":"10.1111","volume":"116","author":[{"given":"Mark J.","family":"McVey","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Pain Medicine University of Toronto Toronto ON Canada"},{"name":"Department of Anesthesia and Pain Medicine SickKids Toronto ON Canada"},{"name":"Department of Physics Ryerson University Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cohen","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Transfusion Medicine and Tissue Bank Department of Laboratory Medicine &amp; Molecular Diagnostics Sunnybrook Health Sciences Centre Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Arsenault","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Department of Pediatrics CHU Sainte\u2010Justine Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alioska","family":"Escorcia","sequence":"additional","affiliation":[{"name":"Blood Transfusion Laboratory (Laboratory Medicine Program) University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzana","family":"Tasmin","sequence":"additional","affiliation":[{"name":"Blood Transfusion Laboratory (Laboratory Medicine Program) University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pendergrast","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Blood Transfusion Laboratory (Laboratory Medicine Program) University Health Network Toronto ON Canada"},{"name":"Department of Medicine (Medical Oncology &amp; Hematology) University Health Network Toronto ON Canada"},{"name":"Department of Medicine Division of Hematology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lani","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Blood Transfusion Laboratory (Laboratory Medicine Program) University Health Network Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5562-9020","authenticated-orcid":false,"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Transfusion Medicine and Tissue Bank Department of Laboratory Medicine &amp; Molecular Diagnostics Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Department of Medicine Division of Hematology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0677","authenticated-orcid":false,"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Transfusion Medicine and Tissue Bank Department of Laboratory Medicine &amp; Molecular Diagnostics Sunnybrook Health Sciences Centre Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Department of Medicine Division of Hematology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-6406","authenticated-orcid":false,"given":"Christine","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Utilization, Efficacy, &amp; Safety of Transfusion (QUEST) Research Program University of Toronto Quality Toronto ON Canada"},{"name":"Department of Laboratory Medicine &amp; Pathobiology University of Toronto Toronto ON Canada"},{"name":"Blood Transfusion Laboratory (Laboratory Medicine Program) University Health Network Toronto ON Canada"},{"name":"Department of Medicine (Medical Oncology &amp; Hematology) University Health Network Toronto ON Canada"},{"name":"Department of Medicine Division of Hematology University of Toronto Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12918"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12573"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2019.05.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003574"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.01.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12502"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-536755"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002687"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15565"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13730"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02816.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14432"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2013.07.002"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000513"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S45873"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002948"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15068"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2018.02.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12070"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12827"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14504"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000074"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2019.09.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13228"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12234"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201504-246OC"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-370932"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15311"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30080-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12830"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13549"},{"key":"e_1_2_7_34_1","unstructured":"TTISS\u2010On.Ontario Guide for Reporting Transfusion Reactions [monograph on the internet].2018. 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