{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:06:56Z","timestamp":1747188416438,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Frequent blood donation depletes iron stores of blood donors. Iron depletion may lead to anaemia, but the health effects of iron depletion without anaemia in healthy blood donors are not well understood. We studied in the FinDonor cohort whether worsening of self\u2010rated health of blood donors during the study period was associated with biomarkers for iron levels or other self\u2010reported changes in lifestyle.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We included 1416 participants from the cohort who answered an 89\u2010item questionnaire on their health and lifestyle during their enrolment visit and again at the end of the study. We performed multivariate logistic regression to test if blood donation\u2010related factors affected the probability of reporting worsened health. To set these findings into a more holistic context of health, we subsequently analysed all other questionnaire items with a data\u2010driven exploratory analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that donation frequency in men and post\u2010menopausal women and ferritin level only in men was associated negatively with worsened health between questionnaires. In the exploratory analysis, stable physical condition was the only questionnaire item that was associated negatively with worsened health in both women and men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest that low ferritin level is associated with worsened health even in non\u2010anaemic repeat donors, although we find that when health is analysed more holistically, ferritin and other factors primarily related to blood donation lose their importance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13104","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T07:03:07Z","timestamp":1618470187000},"page":"1042-1050","source":"Crossref","is-referenced-by-count":3,"title":["Low ferritin levels appear to be associated with worsened health in male repeat blood donors"],"prefix":"10.1111","volume":"116","author":[{"given":"Elina","family":"Palokangas","sequence":"first","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Lobier","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Partanen","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Castr\u00e9n","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-8488","authenticated-orcid":false,"given":"Mikko","family":"Arvas","sequence":"additional","affiliation":[{"name":"Finnish Red Cross Blood Service (FRCBS) Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15136"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03055.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12478"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03956.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12309"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","unstructured":"RigasAS.Iron deficiency among blood donors : experience from the Danish Blood Donor Study and from the Copenhagen ferritin monitoring scheme. 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