{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:44:20Z","timestamp":1787755460787,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Naturally occurring anti\u2010Kp<jats:sup>a<\/jats:sup>antibody is extremely rare and was first reported in 1957, named after the first producer \u2018Penney\u2019. However, the subsequent anti\u2010Kp<jats:sup>a<\/jats:sup>reports presented were all anti\u2010Kp<jats:sup>a<\/jats:sup>due to isoimmunization. Individuals with severe bacterial infections particularly Gram\u2010negative bacteria are known to be capable of producing cross\u2010reactive antibodies against Kell blood group system. However, such uncommon antibodies like anti\u2010Kp<jats:sup>a<\/jats:sup>can be easily missed in routine pre\u2010transfusion testing unless the panel cells containing low incidence antigen are used for antibody screening. Here, we report a case of naturally occurring anti\u2010Kp<jats:sup>a<\/jats:sup>antibody, identified incidentally during pre\u2010transfusion testing of a 12\u2010month\u2010old female infant with the diagnosis of Niemann\u2013Pick disease and recurrent bacterial (<jats:italic>Escherichia coli<\/jats:italic>) infection.<\/jats:p>","DOI":"10.1111\/vox.13122","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T13:16:11Z","timestamp":1623244571000},"page":"133-135","source":"Crossref","is-referenced-by-count":3,"title":["Naturally occurring anti\u2010Kp<sup>a<\/sup>in an infant with recurrent bacterial infection: A case report and review of the literature"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3175-4652","authenticated-orcid":false,"given":"Dhivya","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-2326","authenticated-orcid":false,"given":"Shamee","family":"Shastry","sequence":"additional","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1461-5498","authenticated-orcid":false,"given":"Deepika","family":"Chenna","sequence":"additional","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ponniah Amutha","family":"Prethika","sequence":"additional","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2711-6965","authenticated-orcid":false,"given":"Ashwinkumar","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-6473","authenticated-orcid":false,"given":"Vinu","family":"Rajendran","sequence":"additional","affiliation":[{"name":"Department of Immunohematology &amp; Blood Transfusion, Kasturba Medical College, Manipal Manipal Academy of Higher Education Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"337","volume-title":"Technical Manual","author":"Storry JR","year":"2014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_23_17"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1957.tb03437.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1962.tb03279.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1965.tb01139.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-706"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-174"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.161"},{"key":"e_1_2_6_10_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.4103\/0377-4929.68251","article-title":"Anti Kpa antibody: a rare alloantibody in a multitransfused thalassemic of Indian origin","volume":"53","author":"Pahuja S","year":"2010","journal-title":"Indian J Pathol Microbiol."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-013-0282-z"},{"key":"e_1_2_6_12_1","first-page":"401","article-title":"Antibody screening & identification in the general patient population at a tertiary care hospital in New Delhi, India","volume":"140","author":"Makroo RN","year":"2014","journal-title":"Indian J Med Res"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-230"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2014.08.011"},{"key":"e_1_2_6_15_1","first-page":"222","article-title":"Acute hemolytic transfusion reaction due to anti\u2010Kpa antibody","volume":"71","author":"Sunassee A","year":"2018","journal-title":"S D Med"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.5348\/ijbti-2013-12-CR-3"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00109-14"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1978.18278160576.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28388219149.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.446"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1990.tb02055.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00446"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13122","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13122","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T13:41:05Z","timestamp":1725198065000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,8]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1111\/vox.13122"],"URL":"https:\/\/doi.org\/10.1111\/vox.13122","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,8]]}}}