{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:43:47Z","timestamp":1772502227737,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Shortage of blood during the severe acute respiratory syndrome\u2010COV\u20102 (SARs\u2010COV\u20102) pandemic impacted transfusion practice. The primary aim of the study is to assess management of acute haemolytic crisis (AHC) in glucose\u20106\u2010phosphate dehydrogenase(G6PD)\u2010 deficient children during SARs\u2010COV\u20102 pandemic, and then to assess blood donation situation and the role of telemedicine in management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Assessment of G6PD\u2010deficient children attending the Emergency Department (ER) with AHC from 1 March 2020 for 5\u00a0months in comparison to same period in the previous 2\u2009years, in three paediatric haematology centres. AHC cases presenting with infection were tested for SARs\u2010COV\u20102 using RT\u2010PCR. Children with Hb (50\u201365\u2009g\/L) and who were not transfused, were followed up using telemedicine with Hb re\u2010checked in 24\u2009h.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 45% drop in ER visits due to G6PD deficiency\u2010related AHC during SARs\u2010COV\u20102 pandemic in comparison to the previous 2\u2009years was observed. 10% of patients presented with fever and all tested negative for COVID\u201019 by RT\u2010PCR. 33% of patients had Hb\u2009&lt;\u200950\u2009g\/L and were all transfused. 50% had Hb between 50 and 65\u2009g\/L, half of them (<jats:italic>n<\/jats:italic>\u00a0=\u00a049) did not receive transfusion and only two patients (4%) required transfusion upon follow up. A restrictive transfusion strategy was adopted and one of the reasons was a 39% drop in blood donation in participating centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fewer G6PD\u2010deficient children with AHC visited the ER during SARs\u2010COV\u20102 and most tolerated lower Hb levels. Telemedicine was an efficient tool to support their families. A restrictive transfusion strategy was clear in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13123","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T04:41:50Z","timestamp":1623213710000},"page":"80-86","source":"Crossref","is-referenced-by-count":3,"title":["Management of children with <scp>glucose\u20106\u2010phosphate<\/scp> dehydrogenase deficiency presenting with acute haemolytic crisis during the <scp>SARs\u2010COV<\/scp>\u20102 pandemic"],"prefix":"10.1111","volume":"117","author":[{"given":"Mohsen","family":"Elalfy","sequence":"first","affiliation":[{"name":"Paediatrics Department, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Adly","sequence":"additional","affiliation":[{"name":"Paediatrics Department, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6519-0840","authenticated-orcid":false,"given":"Khadiga","family":"Eltonbary","sequence":"additional","affiliation":[{"name":"Paediatrics Department, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam","family":"Elghamry","sequence":"additional","affiliation":[{"name":"Paediatrics Department, Faculty of Medicine Ain Shams University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Elalfy","sequence":"additional","affiliation":[{"name":"Complementary Medicine Department National Research Center  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Maebid","sequence":"additional","affiliation":[{"name":"Paediatrics Department Faculty of Medicine, Beni\u2010Suef University  Beni Suef 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