{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:54:54Z","timestamp":1780469694158,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Our study sought to evaluate and compare different prediction scores for massive transfusion in\u2010hospital packed red blood cell (PRBC) transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Between January 2013 and December 2018, 1843 trauma patients were enrolled in the registry of a level\u20101 trauma centre. All prehospital and in\u2010hospital variables needed to calculate the Shock Index and RED FLAG, Assessment of Blood Consumption (ABC) and Trauma Associated Severe Hemorrhage (TASH) scores were prospectively collected in the registry. The primary endpoint was the initiation of transfusion within the first hour of the patient's arrival at the hospital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1767 patients were included for analysis with a mean age of 43\u2009years (\u00b119) and a mean Injury Severity Score of 15 (\u00b114). The in\u2010hospital TASH score had the highest predictive performance overall (area under the curve [AUC]\u00a0=\u00a00.925, 95% confidence interval [CI] [0.904\u20130.946]), while the RED FLAG score (AUC\u00a0=\u00a00.881, 95% CI [0.854\u20130.908]) had the greatest prehospital predictive performance compared to the ABC score (AUC\u00a0=\u00a00.798, 95% CI [0.759\u20130.837]) and Shock Index (AUC\u00a0=\u00a00.795, 95% CI [0.752\u20130.837]). Using their standard thresholds, the RED FLAG score was the most efficient in predicting early transfusion (sensitivity: 87%, specificity: 76%, positive predictive value: 25%, negative predictive value: 99%, Youden index: 0.63).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The RED FLAG score appears to outperform both the ABC score and the Shock Index in predicting early in\u2010hospital transfusion in trauma patients managed by pre\u2010hospital teams. If adopted, this score could be used to give advance warning to trauma centres or even to initiate early transfusion during pre\u2010hospital care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13171","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T07:30:51Z","timestamp":1624347051000},"page":"227-234","source":"Crossref","is-referenced-by-count":10,"title":["Early packed red blood cell transfusion in major trauma patients: Evaluation and comparison of different prediction scores for massive transfusion"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8403-0076","authenticated-orcid":false,"given":"Arnaud","family":"Cassignol","sequence":"first","affiliation":[{"name":"SMUR Department Sainte\u2010Musse Public Hospital  Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Bertein","sequence":"additional","affiliation":[{"name":"SMUR Department Sainte\u2010Musse Public Hospital  Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Botti","sequence":"additional","affiliation":[{"name":"Radiology Department University Hospital of Geneva  Gen\u00e8ve Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Renard","sequence":"additional","affiliation":[{"name":"Emergency Department Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Cotte","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Bordes","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department Sainte\u2010Anne Military Hospital  Toulon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07492-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-009-0266-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000199961.02677.19"},{"key":"e_1_2_7_5_1","first-page":"5","article-title":"Early prediction of ongoing hemorrhage in severe trauma: presentation of the existing scoring systems","volume":"20","author":"Tonglet ML","year":"2016","journal-title":"Arch Trauma Res"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181961c35"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3182095a0a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2010.01387.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc9982"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12984"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa052049"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-018-2026-9"},{"key":"e_1_2_7_13_1","first-page":"18","article-title":"Recommendations for uniform reporting of data following major trauma\u2013the Utstein style\u201d (as of July 17, 1999). An international trauma Anaesthesia and critical care society (ITACCS)","volume":"51","author":"Dick WF","year":"2000","journal-title":"Acta Anaesthesiol Belg"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/2531595"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318240507b"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2017.09.015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1106070"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e3181bbf728"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc12851"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2005.02.029"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13040"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2016.12.028"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000001733"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ta.0000220386.84012.bf"},{"key":"e_1_2_7_25_1","first-page":"161","article-title":"Assessing the efficiency of scoring system for predicting the probability of massive transfusion in trauma patients","volume":"02","author":"Subramanian A","year":"2014","journal-title":"J Hematol Thromboembolic Dis"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01466.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/102490791201900306"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11432"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2011.06.010"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13171","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13171","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:00:16Z","timestamp":1692630016000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,22]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1111\/vox.13171"],"URL":"https:\/\/doi.org\/10.1111\/vox.13171","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,22]]}}}