{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:07:01Z","timestamp":1747188421696,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000014","name":"Canadian Blood Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>In Canada, men having sex with men (MSM) are deferred for 3 months from last sexual contact to reduce human immunodeficiency virus (HIV) risk to recipients. The aim of this paper was to model the Canadian residual risk of HIV\u2010positive source plasma incorporating pathogen inactivation (PI) under no MSM deferral scenarios for apheresis plasma donations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A combined Bayesian network (BN) and Monte Carlo approach were implemented to estimate the HIV residual risk under 3\u2010month deferral compared with no deferral without quarantine scenarios for MSM donors. Models involve the stochastic generation of donation and its infection status based on its corresponding simulated donor profile. Viral load reduction conferred by PI used by source plasma fractionators was simulated. Model parameters were derived from H\u00e9ma\u2010Qu\u00e9bec and Canadian Blood Services data, viral loads in a large sample of HIV\u2010positive US blood donors, CSL Behring documentation and from published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the most likely scenario for the 3\u2010month deferral model, there were 2.71 positive donations per 1,000,000 donations (95% confidence interval [CI] 2.63\u20132.78). For the no\u2010deferral model, there were 3.01 positive donations per 1,000,000 donations (95% CI 2.94\u20133.09). For both scenarios, the risk of having an infectious pool was 0 in 300,000 pools (95% CI 0\u20130.0000123) after consideration of PI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on simulation results, there would be a negligible HIV residual risk associated with the removal of a time\u2010based MSM deferral without quarantine for source plasma incorporating PI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13176","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T05:20:29Z","timestamp":1626412829000},"page":"201-207","source":"Crossref","is-referenced-by-count":9,"title":["<scp>HIV<\/scp> residual risk in Canada for apheresis source plasma donation without deferral for men who have sex with men"],"prefix":"10.1111","volume":"117","author":[{"given":"Eliana","family":"Aub\u00e9","sequence":"first","affiliation":[{"name":"Department of Mathematics Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1748-4198","authenticated-orcid":false,"given":"Antoine","family":"Lewin","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Montreal Quebec Canada"},{"name":"Faculty of Medicine and Health Science Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5332-2789","authenticated-orcid":false,"given":"Sheila F.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Epidemiology &amp; Surveillance Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1096-698X","authenticated-orcid":false,"given":"Yves","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josiane","family":"Pillonel","sequence":"additional","affiliation":[{"name":"Direction des Maladies Infectieuses Sant\u00e9 Publique France  St. Maurice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-3115","authenticated-orcid":false,"given":"Whitney R.","family":"Steele","sequence":"additional","affiliation":[{"name":"Scientific Affairs American Red Cross  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Custer","sequence":"additional","affiliation":[{"name":"Epidemiology and Health Policy Science Vitalant Research Institute  San Francisco California USA"},{"name":"Department of Laboratory Medicine UCSF  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-892X","authenticated-orcid":false,"given":"Katy L.","family":"Davison","sequence":"additional","affiliation":[{"name":"Immunisation, Hepatitis &amp; Blood Safety Health Protection Agency  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Germain","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation H\u00e9ma\u2010Qu\u00e9bec  Quebec City Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-4507","authenticated-orcid":false,"given":"Clive R.","family":"Seed","sequence":"additional","affiliation":[{"name":"Donor and Product Safety (DAPS) Policy Unit Australian Red Cross Lifeblood  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-2729","authenticated-orcid":false,"given":"F\u00e9lix","family":"Camirand Lemyre","sequence":"additional","affiliation":[{"name":"Department of Mathematics Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Centre de recherche Centre Hospitalier Universitaire de Sherbrooke  Sherbrooke Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Surveillance, Risk Assessment and Policy Subgroup of the ISBT Transfusion Transmitted Infectious Diseases Working Party","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1111\/j.1537-2995.2010.02851.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/vox.12623"},{"unstructured":"Pathogen Reduction of Platelet Donations as an Alternative Procedure to MSM Donor Deferral. 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