{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T23:26:49Z","timestamp":1775777209640,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Patients who undergo total knee arthroplasty (TKA) have a risk of postoperative anaemia. This observational study evaluated whether single\u2010dose intravenous ferric carboxymaltose (FCM) administered immediately after TKA facilitates the correction of anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We retrospectively analysed 722 patients who underwent primary TKA. The FCM group receiving 1000\u2009mg intravenous FCM within one postoperative hour was compared with the non\u2010FCM group that did not receive the medication. A propensity score matching with multiple logistic regression analysis was used to minimize intergroup differences in the baseline characteristics and postoperative blood loss. The rate and severity of postoperative anaemia were compared between the groups, along with haemoglobin (Hb) value, transfusion rate and complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score matching, 231 patients were included in each group. In the FCM group, the rate of anaemia at postoperative day (POD) 7 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) and postoperative week (POW) 5 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and the transfusion rate were significantly lower (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). The rate of moderate to severe anaemia at POW\u20105 was also significantly lower in the FCM group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In patients without preoperative anaemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a0322), the transfusion rate and rate and severity of anaemia at POD\u20107 and POW\u20105 were significantly lower in the FCM group than in the non\u2010FCM group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Postoperative intravenous FCM administration facilitated recovery of surgery\u2010related anaemia by improving Hb and may reduce the need for transfusion in TKA patients. Preoperative non\u2010anaemic patients could also benefit from accelerated recovery by intravenous iron treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13181","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T15:54:03Z","timestamp":1626450843000},"page":"243-250","source":"Crossref","is-referenced-by-count":8,"title":["Immediate intravenous iron administration improves anaemia recovery following total knee arthroplasty: A propensity\u2010matched analysis"],"prefix":"10.1111","volume":"117","author":[{"given":"Hee\u2010Sun","family":"Park","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Il","family":"Bin","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ha\u2010Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngjin","family":"Ro","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine, 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