{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:41:05Z","timestamp":1781764865858,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>While iron deficiency (ID) is the most common cause of anaemia, little is known about the prevalence and type of ID in preoperative surgical patients. The aims of the present study were to investigate the prevalence and types of ID in a large cohort of surgical patients, and how these are related to perioperative blood use after correction for confounders such as haemoglobin level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data were retrospectively extracted from electronic case records of all patients who underwent elective surgery between September 2016 and November 2017 (<jats:italic>n<\/jats:italic>\u00a0=\u00a02711). Iron parameters, haemoglobin and details of perioperative red cell transfusions were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2711 patients, 618 (22.8%) were iron deficient (= transferrin saturation [TSAT] &lt;\u200916%) preoperatively, 173 (6.4% of the cohort) had an absolute iron deficiency (AID; TSAT &lt;\u200916% and ferritin &lt;\u200930\u00a0\u03bcg\/L) and 445 (16.4%) had functional\/mixed ID (TSAT &lt;\u200916% and ferritin \u2265\u200930\u00a0\u03bcg\/L). Corrected for Hb level, iron\u2010deficient patients received significantly more red cell units than patients without ID (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026). AID was not associated with a significantly higher incidence of transfusions (7.5% of patients transfused; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.12 after correction for Hb) than patients without ID, whereas patients with functional\/mixed deficiency did receive significantly more transfusions (6.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.021) as compared to patients without ID (1.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative ID, in particular the functional\/mixed type, was associated with a higher risk of receiving perioperative red cell transfusions as compared to patients without ID. Adequately treating ID might, therefore, reduce the need for perioperative red cell transfusions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13194","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T10:21:45Z","timestamp":1629800505000},"page":"379-385","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of iron deficiency and red blood cell transfusions in surgical patients"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-6617","authenticated-orcid":false,"given":"Rik Paulus Bernardus","family":"Tonino","sequence":"first","affiliation":[{"name":"Haematology Haga Teaching Hospital  The Hague The Netherlands"},{"name":"TRIP Haemovigilance and Biovigilance Office  Leiden The Netherlands"},{"name":"Haematology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wilson","sequence":"additional","affiliation":[{"name":"Surgery Erasmus Medical Centre  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"TRIP Haemovigilance and Biovigilance Office  Leiden The Netherlands"},{"name":"Haematology Leiden University Medical Centre  Leiden The Netherlands"},{"name":"CCTR Sanquin Blood Supply  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Roelof","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Haematology Haga Teaching Hospital  The Hague The Netherlands"},{"name":"TRIP Haemovigilance and Biovigilance Office  Leiden The Netherlands"},{"name":"CCTR Sanquin Blood Supply  Amsterdam The Netherlands"},{"name":"Haematology University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes139"},{"key":"e_1_2_7_3_1","first-page":"297","article-title":"Getting patient blood management pillar 1 right in the Asia\u2010Pacific: a call for action","volume":"61","author":"Abdullah H","year":"2019","journal-title":"Singap Med J"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001646"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes135"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181e08e97"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13773"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24820"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X0102900504"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2015.08.017"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.1161"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161296298"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs344"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000291441.10704.82"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10328"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14659"},{"key":"e_1_2_7_17_1","unstructured":"WHO Geneva World Health Organisation Nutritional anaemias: tools for effective prevention and control"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.195552"},{"key":"e_1_2_7_19_1","unstructured":"2001 WHO Geneva United nations World Health Organisation Iron deficiency anaemia assessment prevention and control: a guide for programme managers"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60865-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32555-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4822"},{"key":"e_1_2_7_23_1","first-page":"8","article-title":"On the role of iron therapy for reducing allogeneic blood transfusion in orthopaedic surgery","volume":"10","author":"Mu\u00f1oz M","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003643"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.02.006"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e32834ad97b"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2009.03.007"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31539-7"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00216-6"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13194","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13194","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T06:51:24Z","timestamp":1693119084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/vox.13194"],"URL":"https:\/\/doi.org\/10.1111\/vox.13194","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]}}}