{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:19:47Z","timestamp":1788715187893,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010dependent \u03b2\u2010thalassaemia can lead to severe psychological issues in paediatric and adolescent patients. However, the psychological interventions for these patients are limited in clinical practice. We aimed to investigate the impact of a 3\u2010month psychological intervention on the quality of life (<jats:styled-content style=\"fixed-case\">QOL)<\/jats:styled-content> of children with \u03b2\u2010thalassaemia (12\u201318\u2009years old) who relied on blood transfusion in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In the current randomized controlled trial, a total of 143 paediatric or adolescent patients (12\u201318\u2009years old) with transfusion\u2010dependent \u03b2\u2010thalassaemia were recruited. They were randomized into the control group (<jats:italic>n<\/jats:italic>\u00a0=\u00a071) who received standard physiological treatment and the intervention group (<jats:italic>n<\/jats:italic>\u00a0=\u00a072) who received a 3\u2010month intervention in addition to standard physiological treatment. The effects of the interventions on the QOL and psychological outcomes of these participants were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010month intervention significantly improved the scores of PedsQoL 4.0 Generic Core Scales of paediatric patients with transfusion\u2010dependent \u03b2\u2010thalassaemia. It also significantly improved the psychological status and alleviated the depression among children and adolescent patients by alleviating anhedonia, negative mood and negative self\u2010esteem among them.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Psychological intervention has positive effects on the treatment for children with transfusion\u2010dependent \u03b2\u2010thalassaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13201","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T08:39:18Z","timestamp":1631263158000},"page":"386-392","source":"Crossref","is-referenced-by-count":8,"title":["Psychological intervention in children with transfusion\u2010dependent \u03b2\u2010thalassaemia"],"prefix":"10.1111","volume":"117","author":[{"given":"Meichun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Quanzhou First Hospital  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Quanzhou First Hospital  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2789-6508","authenticated-orcid":false,"given":"Yijin","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Quanzhou First Hospital  Quanzhou Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.173"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11"},{"key":"e_1_2_7_4_1","first-page":"339","article-title":"Alpha and beta thalassemia","volume":"80","author":"Muncie HL","year":"2009","journal-title":"Am Fam 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