{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:23:24Z","timestamp":1789323804769,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Platelets for transfusion have a shelf\u2010life of 7\u2009days, limiting availability and leading to wastage. Cryopreservation at \u221280\u00b0C extends shelf\u2010life to at least 1\u2009year, but safety and effectiveness are uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This single centre blinded pilot trial enrolled adult cardiac surgery patients who were at high risk of platelet transfusion. If treating clinicians determined platelet transfusion was required, up to three units of either cryopreserved or liquid\u2010stored platelets intraoperatively or during intensive care unit admission were administered. The primary outcome was protocol safety and feasibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over 13\u2009months, 89 patients were randomized, 23 (25.8%) of whom received a platelet transfusion. There were no differences in median blood loss up to 48\u2009h between study groups, or in the quantities of study platelets or other blood components transfused. The median platelet concentration on the day after surgery was lower in the cryopreserved platelet group (122\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\/\u03bcl vs. 157\u2009\u00d7\u200910<jats:sup>3<\/jats:sup>\/\u03bcl, median difference 39.5\u00a0\u00d710<jats:sup>3<\/jats:sup>\/\u03bcl, <jats:italic>p<\/jats:italic>\u00a0=\u20090.03). There were no differences in any of the recorded safety outcomes, and no adverse events were reported on any patient. Multivariable adjustment for imbalances in baseline patient characteristics did not find study group to be a predictor of 24\u2010h blood loss, red cell transfusion or a composite bleeding outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This pilot randomized controlled trial demonstrated the feasibility of the protocol and adds to accumulating data supporting the safety of this intervention. Given the clear advantage of prolonged shelf\u2010life, particularly for regional hospitals in New Zealand, a definitive non\u2010inferiority phase III trial is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13203","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T10:57:03Z","timestamp":1632826623000},"page":"337-345","source":"Crossref","is-referenced-by-count":21,"title":["A pilot randomized clinical trial of cryopreserved versus liquid\u2010stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet<scp>\u2010<\/scp>New Zealand pilot trial"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-4787","authenticated-orcid":false,"given":"Shay","family":"McGuinness","sequence":"first","affiliation":[{"name":"Cardiothoracic and Vascular Intensive Care Unit Auckland City Hospital  Auckland New Zealand"},{"name":"Medical Research Institute of New Zealand  Wellington 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Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renae","family":"Deans","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland, Royal Brisbane and Women's Hospital  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Howe","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-4437","authenticated-orcid":false,"given":"Lacey","family":"Johnson","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3674-6934","authenticated-orcid":false,"given":"Denese C.","family":"Marks","sequence":"additional","affiliation":[{"name":"Australian Red Cross Lifeblood  Alexandria New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1570-0707","authenticated-orcid":false,"given":"Michael C.","family":"Reade","sequence":"additional","affiliation":[{"name":"Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine Monash University  Melbourne Victoria Australia"},{"name":"Faculty of Medicine University of Queensland, Royal Brisbane and Women's Hospital  Herston Queensland Australia"},{"name":"Joint Health Command Australian Defence Force  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Australian and New Zealand College of Anaesthetists Clinical Trials Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Australian and 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