{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T21:13:22Z","timestamp":1771190002663,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:00:00Z","timestamp":1639267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Limited data are available to guide physicians on how to determine the red blood cell (RBC) transfusion regimen in chronically transfusion\u2010dependent patients. The lack of clarity on thresholds and targets to be used for transfusion could easily result in either under or over transfusion in these patients. The aim of our survey is to investigate (1) transfusion thresholds; (2) number of RBC units given per transfusion episode; (3) interval between transfusions and (4) patient factors, like decreased cardiac function modulating the former.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We sent a web\u2010based 44\u2010question survey to members of the Dutch Haematology Association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty physicians responded between June and October 2020 (response rate 30%), well\u2010distributed between community and academic hospitals. A wide variation in transfusion strategies was reported: Most patients have transfused 1\u20132 RBC units (range: 0\u20133\u00a0units) every 2\u20134\u2009weeks (range: 1\u201312\u2009weeks) with a median threshold of 8.0\u00a0g\/dl ranging from 6.4 to 9.6\u00a0g\/dl. Patient\u2010specific clinical factors that are most frequently reported to influence the transfusion strategy are angina pectoris, cardiac failure and dyspnoea, softer parameters that are of influence are the quality of life and self\u2010sustainability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of this survey indicate a broad variation in RBC transfusion strategies in Dutch patients with chronic transfusion dependency. While the current variation in transfusion strategies may be unavoidable in an individualized approach, randomized trials and better defined usable parameters to evaluate the effect of transfusion strategies are required to reach a consensus on how to determine the transfusion strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13220","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T05:52:58Z","timestamp":1639374778000},"page":"526-534","source":"Crossref","is-referenced-by-count":2,"title":["Clinical practice for outpatients that are chronically red cell dependent: A survey in the Netherlands"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-6617","authenticated-orcid":false,"given":"Rik P. B.","family":"Tonino","sequence":"first","affiliation":[{"name":"Haematology LUMC  Leiden The Netherlands"},{"name":"Haematology Haga Teaching Hospital  The Hague The Netherlands"},{"name":"Research TRIP Haemovigilance and Biovigilance Office  The Hague The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin R.","family":"Schipperus","sequence":"additional","affiliation":[{"name":"Haematology Haga Teaching Hospital  The Hague The Netherlands"},{"name":"Research TRIP Haemovigilance and Biovigilance Office  The Hague The Netherlands"},{"name":"CTCR Sanquin Blood Supply  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaap Jan","family":"Zwaginga","sequence":"additional","affiliation":[{"name":"Haematology LUMC  Leiden The Netherlands"},{"name":"Research TRIP Haemovigilance and Biovigilance Office  The Hague The Netherlands"},{"name":"CTCR Sanquin Blood Supply  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12435"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13342"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04272.x"},{"key":"e_1_2_8_5_1","article-title":"Comparison of a restrictive versus liberal red cell transfusion policy for patients with myelodysplasia, aplastic anaemia, and other congenital bone marrow failure disorders","volume":"10","author":"Gu Y","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","first-page":"28","article-title":"Blood management by transfusion triggers: when less is more","volume":"10","author":"Ansari S","year":"2012","journal-title":"Blood Transfus"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21503"},{"key":"e_1_2_8_8_1","article-title":"Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion","volume":"10","author":"Carson JL","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usy279"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15371"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2017.06.054"},{"key":"e_1_2_8_12_1","first-page":"307","article-title":"Red blood cell transfusion policy: a critical literature review","volume":"15","author":"Franchini M","year":"2017","journal-title":"Blood Transfus"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14641"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.11.002"},{"key":"e_1_2_8_15_1","first-page":"102","article-title":"De Richtlijn Bloedtransfusie 2011","volume":"4","author":"Haas F","year":"2011","journal-title":"Tijdschr voor Bloedtransfus"},{"key":"e_1_2_8_16_1","unstructured":"KittangAO CavelierL DybedalI EbelingF EjerbladE LoneF et al.Guidelines for the diagnosis and treatment of myelodysplastic syndromes and chronic myelomonocytic leukemia2014;7:1\u201350."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01485.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003364"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq336"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.08.027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50313.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31819d89d5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52208.x"},{"key":"e_1_2_8_24_1","first-page":"1","article-title":"Aandacht voor secundaire ijzerstapeling bij hemato\u2010oncologie pati\u00ebnten_ overbodig of broodnodig","volume":"3","author":"Verwimp\u2010Hoeks MPA","year":"2015","journal-title":"Tijdschr voor Bloedtransfus"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2006.0007"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2010.09.006"},{"key":"e_1_2_8_27_1","first-page":"5","article-title":"A Technique for the measurement of attitudes","volume":"22","author":"Likert R","year":"1932","journal-title":"Arch Psychol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-194209000-00032"},{"key":"e_1_2_8_29_1","unstructured":"Nederlandse Internisten Vereniging.Bloedtransfusiebeleid Inhoudsopgave. [Internet];2019[cited 2021 Oct 7]. Available from:https:\/\/richtlijnendatabase.nl\/richtlijn\/bloedtransfusiebeleid\/transfusiebeleid_bij_de_niet_acuut_bloedende_patient.html"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12617"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13434"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15708"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16347"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13220","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13220","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T15:45:55Z","timestamp":1692978355000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,12]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/vox.13220"],"URL":"https:\/\/doi.org\/10.1111\/vox.13220","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,12]]}}}