{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T14:47:12Z","timestamp":1790952432588,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070198"],"award-info":[{"award-number":["82070198"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The transfusion of D\u2010negative red blood cells (RBCs) to D\u2010negative patients has been widely adopted to prevent anti\u2010D alloimmunization, especially in women of childbearing age. Still, transfusion of D\u2010positive RBCs to D\u2010negative recipients is occasionally inevitable in practice, and the resulting incidence of anti\u2010D in different D\u2010negative groups of patients has not been well summarized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>We searched the relevant literature using PubMed, Cochrane Library, and Embase databases from inception date to 30 September 2021. We looked for studies of anti\u2010D occurring in D\u2010negative recipients who received D\u2010positive RBC transfusions. The anti\u2010D incidence was summarized with 95% confidence intervals (CIs). Data with similar characteristics were combined using a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 42 studies (2226 cases), which found anti\u2010D, the exact volume of D\u2010positive RBC transfused, and the follow\u2010up time for anti\u2010D detection, met the inclusion criteria. The pooled anti\u2010D incidence was 64% (95% CI, range 55%\u201374%) in volunteers receiving small volumes of D\u2010positive RBCs, 84% (95% CI, 74%\u201394%) in those receiving whole units, 26% (95% CI, 19%\u201332%) in mixed patients, 12% (95% CI, 8%\u201316%) in oncology patients, 27% (95% CI, 13%\u201340%) in trauma patients, 4% (95% CI, 0%\u20138%) in immune\u2010compromised transplant patients, and 6% (95% CI, 1%\u201339%) in those with AIDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with the high frequency of anti\u2010D in healthy D\u2010negative volunteers given D\u2010positive RBCs, we found a lower rate of anti\u2010D immunization in various D\u2010negative patients and almost none in transplant and AIDS patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13232","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T07:16:44Z","timestamp":1641885404000},"page":"633-640","source":"Crossref","is-referenced-by-count":29,"title":["Incidence of <scp>anti\u2010D<\/scp> alloimmunization in D\u2010negative individuals receiving D\u2010positive red blood cell transfusion: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-5612","authenticated-orcid":false,"given":"Yanli","family":"Ji","sequence":"first","affiliation":[{"name":"Institute of Clinical Blood Transfusion Guangzhou Blood Center  Guangzhou People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangping","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Clinical Blood Transfusion Guangzhou Blood Center  Guangzhou People's Republic of 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