{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T08:43:32Z","timestamp":1775292212202,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>The adrenaline\u2010takotsubo\u2010anaphylaxis\u2010Kounis, or the ATAK complex, where there are clinical and pathophysiological overlaps between takotsubo and Kounis syndromes, in which histaminergic, adrenergic and other mediators may play roles, was recently described. The objective of this report was to describe three cases where the ATAK complex was suspected to have occurred after transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three cases were recently reported to the New Zealand Blood Service haemovigilance programme that appeared to have features in common suggestive of the ATAK complex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All three patients had had a blood component transfused, an initial severe allergic reaction, treatment with adrenaline or a congener, subsequent acute left ventricular failure or transfusion\u2010associated circulatory overload, and features suggestive of takotsubo cardiomyopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although rarely described, transfusion\u2010associated ATAK complex may be occurring more often than believed. Circumstances during a transfusion may predispose to it. It should be suspected if the sequence of events described above occur. Its characteristics need to be better understood. Risk factors for it may be modifiable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13257","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T06:53:02Z","timestamp":1645512782000},"page":"862-865","source":"Crossref","is-referenced-by-count":3,"title":["Transfusion double whammy? <scp>Adrenaline\u2010takotsubo\u2010anaphylaxis\u2010Kounis<\/scp> complex post transfusion?"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-3792","authenticated-orcid":false,"given":"Krishna G.","family":"Badami","sequence":"first","affiliation":[{"name":"New Zealand Blood Service  Addington New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"International Society of Blood Transfusion.Working party on Haemovigilance. Proposed standard definitions for surveillance of non\u2010infectious adverse transfusion reactions."},{"key":"e_1_2_9_3_1","volume-title":"Transfusion reactions","author":"Kopko PM","year":"2021"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.072"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.6020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0b013e32833cdbb0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.11.088"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jccase.2019.03.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.171410"},{"key":"e_1_2_9_11_1","first-page":"465","article-title":"Peri\u2010anesthesia anaphylaxis (PAA): we still have not started post\u2010PAA testing for inciting anesthesia\u2010related allergens","volume":"23","author":"Alshaeri T","year":"2016","journal-title":"Middle East J Anaesthesiol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.07.03"},{"key":"e_1_2_9_13_1","unstructured":"RahmanA LiuD.Broken heart syndrome a case studyhttps:\/\/www.racgp.org.au\/download\/documents\/AFP\/2012\/JanFeb\/201201rahman.pdf. Accessed 03 Dec 2021."},{"key":"e_1_2_9_14_1","first-page":"30","article-title":"Stress\u2010induced cardiomyopathy associated with a transfusion reaction: a case of potential crosstalk between the histaminic and adrenergic systems","volume":"16","author":"Zhou JQ","year":"2011","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.01.062"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13257","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13257","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13257","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T09:37:54Z","timestamp":1692869874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/vox.13257"],"URL":"https:\/\/doi.org\/10.1111\/vox.13257","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]}}}