{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:54:43Z","timestamp":1776376483397,"version":"3.51.2"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Donor eligibility questions and criteria for medical conditions vary between blood centres, suggesting that they are based more on local regulations or experience, rather than on published data, which are limited. As the donor population ages, medical conditions become more common. We assessed donor health assessment criteria at blood centre members of the Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Our aim was to compare eligibility criteria and determine their underlying basis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A REDCap survey was sent to blood centre participants, based on medical conditions of greatest interest suggested by the Donor Studies Team of the BEST Collaborative. Participants were asked about current donor health assessment questions, deferral criteria and the basis for their deferral policy (donor risk, recipient risk or both) for 20 medical conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete responses were received from 26 blood donor centres (24 separate responses) representing a combination of hospital\u2010based centres, large regional centres and community\/national blood centres in 14 different countries. Most centres specifically ask about heart and lung conditions, whereas fewer than half inquire about kidney, gastrointestinal or neurological conditions. North American blood centres tended to be less restrictive, while regulatory restrictions are more prevalent in Europe. Most participants felt that the criteria were based on regulatory requirements or experience, rather than on published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is considerable variability in criteria by region. Ideally, criteria would be more evidence\u2010based rather than based on regulatory requirements or experience. Deferral criteria must balance donor and recipient safety and maintain an adequate blood supply.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13281","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T17:24:05Z","timestamp":1649697845000},"page":"929-936","source":"Crossref","is-referenced-by-count":10,"title":["Blood donor eligibility criteria for medical conditions: A <scp>BEST<\/scp> collaborative study"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-0644","authenticated-orcid":false,"given":"Cyril","family":"Jacquot","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Children's National Hospital  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9310-8322","authenticated-orcid":false,"given":"Pierre","family":"Tiberghien","sequence":"additional","affiliation":[{"name":"International Medical and Scientific Research Etablissement Fran\u00e7ais du Sang  La Plaine Saint\u2010Denis France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"van den Hurk","sequence":"additional","affiliation":[{"name":"Donor Studies, Sanquin Research Sanquin  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-9319","authenticated-orcid":false,"given":"Alyssa","family":"Ziman","sequence":"additional","affiliation":[{"name":"Clinical and Laboratory Pathology University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2270-4821","authenticated-orcid":false,"given":"Beth","family":"Shaz","sequence":"additional","affiliation":[{"name":"Department of Pathology Duke University School of Medicine  Durham North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torunn Oveland","family":"Apelseth","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9904-9952","authenticated-orcid":false,"given":"Mindy","family":"Goldman","sequence":"additional","affiliation":[{"name":"Medical Affairs and Innovation Canadian Blood Services  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Biomedical Excellence for Safer Transfusion (BEST) Collaborative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2009.03.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.20257"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jca.10031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13028"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13054"},{"key":"e_1_2_8_7_1","first-page":"101","article-title":"Blood donor selection in European Union directives: room for improvement","volume":"14","author":"De Kort W","year":"2016","journal-title":"Blood Transfus"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"e_1_2_8_10_1","volume-title":"Screening blood donors with the donor history questionnaire","author":"O'Brien SF","year":"2019"},{"key":"e_1_2_8_11_1","unstructured":"AABB Donor History Questionnaire v2.1 2020[cited 2022 Jan 7]. Available from:https:\/\/www.aabb.org\/docs\/default-source\/default-document-library\/resources\/dhq-v2-1\/pdfs\/dhq-v2-1-prep-pep-art.pdf"},{"key":"e_1_2_8_12_1","unstructured":"Code of Federal Regulations.Part 630 \u2013 Requirements for Blood and Blood Components Intended for Transfusion or for Further Manufacturing Use[cited 2022 Jan 7]. Available from:https:\/\/www.ecfr.gov\/current\/title-21\/chapter-I\/subchapter-F\/part-630"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16574"},{"key":"e_1_2_8_14_1","unstructured":"Commission Directive 2004\/33\/EC of 22 March 2004[cited 2022 Jan 7]. Available from:https:\/\/www.ema.europa.eu\/en\/documents\/regulatory\u2010procedural\u2010guideline\/commission\u2010directive\u20102004\/33\/ec\u201022\u2010march\u20102004\u2010implementing\u2010directive\u20102002\/98\/ec\u2010european\u2010parliament\u2010council\u2010regards\u2010certain\u2010technical\u2010requirements\u2010blood\u2010blood\u2010components_en.pdf"},{"key":"e_1_2_8_15_1","unstructured":"Council of Europe guide to the preparation use and quality assurance of blood components. 20th ed [cited 2022 Jan 7]. Available from:https:\/\/www.edqm.eu\/en\/blood-guide"},{"key":"e_1_2_8_16_1","volume-title":"Screening blood donors with the donor history questionnaire","author":"Grima KM","year":"2019"},{"key":"e_1_2_8_17_1","volume-title":"Screening blood donors with the donor history questionnaire","author":"Land KJ","year":"2019"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2015.05.003"},{"key":"e_1_2_8_19_1","volume-title":"Screening blood donors with the donor history questionnaire","author":"Eder A","year":"2019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054494"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2017.97"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302984"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30114-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13014"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60779-X"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2421"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13281","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T02:13:00Z","timestamp":1692843180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,11]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/vox.13281"],"URL":"https:\/\/doi.org\/10.1111\/vox.13281","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"value":"0042-9007","type":"print"},{"value":"1423-0410","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,11]]}}}