{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:27:51Z","timestamp":1761294471800,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009425","name":"Landsteiner Foundation for Blood Transfusion Research","doi-asserted-by":"publisher","award":["1931F"],"award-info":[{"award-number":["1931F"]}],"id":[{"id":"10.13039\/100009425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vox Sanguinis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Transfusion\u2010associated circulatory overload (TACO) is a major cause of severe transfusion\u2010related morbidity. Transfusion of red blood cells (RBCs) has been shown to induce hydrostatic pressure overload. It is unclear which product\u2010specific factors contribute. We set out to determine the effect of autologous RBC transfusion versus saline on pulmonary capillary wedge pressure (PCWP) change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In a randomized crossover trial, patients who had undergone coronary bypass surgery were allocated to treatment post\u2010operatively in the intensive care unit with either an initial 300\u2009ml autologous RBC transfusion (salvaged during surgery) or 300\u2009ml saline infusion first, followed by the other. Primary outcome was the difference in PCWP change. Secondary outcome measures were the difference in extra\u2010vascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Change in PCWP was not higher after autologous RBC transfusion compared to saline (\u0394PCWP 0.3\u2009\u00b1\u20090.4 vs. 0.1\u2009\u00b1\u20090.4\u2009mmHg). \u0394EVLWI and \u0394PVPI were significantly decreased after autologous RBC transfusion compared to saline (\u0394EVLWI \u22121.6\u2009\u00b1\u20090.6 vs. 0.2\u2009\u00b1\u20090.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02; \u0394PVPI \u22120.3\u2009\u00b1\u20090.1 vs. 0.0\u2009\u00b1\u20090.1, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Haemodynamic variables and colloid osmotic pressure were not different for autologous RBC transfusion versus saline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transfusion of autologous RBCs did not result in a more profound increase in PCWP compared to saline. RBC transfusion resulted in a decrease of EVLWI and PVPI compared to saline. Our data suggest that transfusing autologous RBCs may lead to less pulmonary oedema compared to saline. Future studies with allogeneic RBCs are needed to investigate other factors that may mediate the increase of PCWP, resulting in TACO.<\/jats:p><\/jats:sec>","DOI":"10.1111\/vox.13292","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T09:11:16Z","timestamp":1652433076000},"page":"1035-1042","source":"Crossref","is-referenced-by-count":2,"title":["Autologous red blood cell transfusion does not result in a more profound increase in pulmonary capillary wedge pressure compared to saline in critically ill patients: A randomized crossover trial"],"prefix":"10.1111","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0149-7349","authenticated-orcid":false,"given":"Joachim J.","family":"Bosboom","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Intensive Care, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5820-4530","authenticated-orcid":false,"given":"Robert B.","family":"Klanderman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Intensive Care, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lotte E.","family":"Terwindt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther B.","family":"Bulle","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marije","family":"Wijnberge","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Intensive Care, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Eberl","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoine H.","family":"Driessen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toon A.","family":"Winkelman","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart F.","family":"Geerts","sequence":"additional","affiliation":[{"name":"Healthplus.ai\u2010R&amp;D B.V.  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise P.","family":"Veelo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus W.","family":"Hollmann","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander P. J.","family":"Vlaar","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"},{"name":"Laboratory of Experimental Intensive Care and Anesthesiology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1612789"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01313-6"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14432"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.01.003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12454"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02748.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2012.03595.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12473"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12965"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12070"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001506"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.26.759"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978303401102"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213000"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201405-0850OC"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03231.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.019"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002948"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c332"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2014.08.003"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182975b85"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aet590"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30080-8"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-017-1739-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/0470854596"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.111302"},{"key":"e_1_2_8_28_1","first-page":"571","volume-title":"Handbook of statistics","author":"Tudor GE","year":"2000"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15122"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12032"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44551"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1586\/ers.09.49"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12932"}],"container-title":["Vox Sanguinis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vox.13292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vox.13292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:55:41Z","timestamp":1692842141000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vox.13292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/vox.13292"],"URL":"https:\/\/doi.org\/10.1111\/vox.13292","archive":["Portico"],"relation":{},"ISSN":["0042-9007","1423-0410"],"issn-type":[{"type":"print","value":"0042-9007"},{"type":"electronic","value":"1423-0410"}],"subject":[],"published":{"date-parts":[[2022,5,13]]}}}